Toluene-4-sulfonic acid 2-(2,3-dimethoxy-7-nitro-quinoxalin-5-yl)-ethyl ester | 203719-99-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Toluene-4-sulfonic acid 2-(2,3-dimethoxy-7-nitro-quinoxalin-5-yl)-ethyl ester
• CAS: 203719-99-7
• 化学式: C₁₉H₁₉N₃O₇S
• 分子量: 433.442
• InChiKey: NLJHPAHLIJHVSI-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  Toluene-4-sulfonic acid 2-(2,3-dimethoxy-7-nitro-quinoxalin-5-yl)-ethyl ester 在 盐酸 作用下， 反应 8.0h， 生成 1-[2-(7-Nitro-2,3-dioxo-1,2,3,4-tetrahydro-quinoxalin-5-yl)-ethyl]-piperidine-4-carboxylic acid
  参考文献：
  名称：

  5-aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists

  摘要：

  A series of 5-aminomethylquinoxaline-2,3-diones have been identified as potent and selective AMPA antagonists. Some of these compounds are also active at the glycine-binding site of the NMDA receptors. A number of these novel, water-soluble quinoxaline-2,3-dione derivatives display protective effects in the electroshock-induced convulsion model in mice. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(97)10186-x
• 作为产物：
  描述：

  2,3-dimethoxy-5-bromo-7-nitro-quinoxaline 在 吡啶 、 9-borabicyclo[3.3.1]nonane dimer 、 四(三苯基膦)钯 、 双氧水 、 sodium carbonate 作用下， 以 甲苯 为溶剂， 生成 Toluene-4-sulfonic acid 2-(2,3-dimethoxy-7-nitro-quinoxalin-5-yl)-ethyl ester
  参考文献：
  名称：

  5-aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists

  摘要：

  A series of 5-aminomethylquinoxaline-2,3-diones have been identified as potent and selective AMPA antagonists. Some of these compounds are also active at the glycine-binding site of the NMDA receptors. A number of these novel, water-soluble quinoxaline-2,3-dione derivatives display protective effects in the electroshock-induced convulsion model in mice. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(97)10186-x