diisopropyl 2-(4-acetoxyphenyl)-1-aminoethylphosphonate | 946009-00-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diisopropyl 2-(4-acetoxyphenyl)-1-aminoethylphosphonate
• CAS: 946009-00-3
• 化学式: C₁₆H₂₆NO₅P
• 分子量: 343.36
• InChiKey: VEXYLZYKOCMUFU-UHFFFAOYSA-N

物化性质

• 沸点：
  453.7±45.0 °C(Predicted)
• 密度：
  1.142±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.48
• 重原子数：
  23.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  87.85
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  diisopropyl 2-(4-acetoxyphenyl)-1-aminoethylphosphonate 在 盐酸 作用下， 反应 28.0h， 以87%的产率得到1-amino-2-(4-hydroxyphenyl)ethylphosphonic acid hydrochloride
  参考文献：
  名称：

  Indium triflate catalyzed reaction of diisopropyl diazomethylphosphonate with imines as a new approach to cis- and trans-aziridine-2-phosphonates

  摘要：

  A new and efficient synthesis of cis- and trans-aziridine-2-phosphonates by metal-catalyzed aziridination reaction of diisopropyl diazomethylphosphonate and substituted aryl imines is reported. By exploring the influence of different Lewis acids employed as catalysts, imine nitrogen substituents, and the solvent effects we conclude that the best results are obtained when N-d iphenylmethyl- substituted benzylimines are reacted with diisopropyl diazomethylphosphonate in methylene chloride at 0 degrees C in the presence of In(OTt)(3) as catalyst. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.05.042
• 作为产物：
  描述：

  4-乙酰氧基苯甲醛 在 palladium on activated charcoal 、 In(OSO₂CF₃)3 molecular sieve 、 氢气 、 sodium sulfate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 5.0h， 生成 diisopropyl 2-(4-acetoxyphenyl)-1-aminoethylphosphonate
  参考文献：
  名称：

  Indium triflate catalyzed reaction of diisopropyl diazomethylphosphonate with imines as a new approach to cis- and trans-aziridine-2-phosphonates

  摘要：

  A new and efficient synthesis of cis- and trans-aziridine-2-phosphonates by metal-catalyzed aziridination reaction of diisopropyl diazomethylphosphonate and substituted aryl imines is reported. By exploring the influence of different Lewis acids employed as catalysts, imine nitrogen substituents, and the solvent effects we conclude that the best results are obtained when N-d iphenylmethyl- substituted benzylimines are reacted with diisopropyl diazomethylphosphonate in methylene chloride at 0 degrees C in the presence of In(OTt)(3) as catalyst. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.05.042