4-(1,3-二氧戊环-4-基)丁烷-1-醇 | 3357-46-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 中文名称: 4-(1,3-二氧戊环-4-基)丁烷-1-醇
• 英文名称: 1,3-Dioxolane-4-butanol
• 英文别名: 4-(1,3-dioxolan-4-yl)butan-1-ol
• CAS: 3357-46-8
• 化学式: C₇H₁₄O₃
• 分子量: 146.18
• InChiKey: KRNYIXPUTGIQOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• LIPID DERIVATIVE IN WHICH HYDROPHILIC POLYMERS ARE BOUND VIA CYCLIC BENZYLIDENE ACETAL LINKERS
  申请人：NOF Corporation

  公开号：EP3357514A1

  公开（公告）日：2018-08-08

  To provide a lipid derivative in which a hydrophilic polymer is bound through an acetal linker, and which can accurately control a hydrolysis rate at the pH of the weakly acidic environment in the living body to detach the hydrophilic polymer from a lipid membrane structure. A lipid derivative in which a hydrophilic polymer is bound through a cyclic benzylidene acetal linker represented by formula (1) : wherein, R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; R7 is a hydrocarbon group having from 8 to 24 carbon atoms, an acyl group having from 8 to 24 carbon atoms, a cholesterol derivative, a glycerolipid, a phospholipid or a sphingolipid; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s + t is 1 or 2; and Z1 and Z2 are each independently a selected divalent spacer.

  提供一种脂质衍生物，其中亲水性聚合物通过乙缩醛连接体结合，并能在生物体内弱酸性环境的 pH 值下准确控制水解速度，使亲水性聚合物从脂质膜结构中分离。一种脂质衍生物，其中的亲水性聚合物通过环状亚苄基缩醛连接体结合，连接体由式（1）表示： 其中，R1 和 R6 各自独立地为氢原子或烃基；R2、R3、R4 和 R5 各自独立地为取电子或供电子取代基或氢原子；R7 是具有 8 至 24 个碳原子的烃基、具有 8 至 24 个碳原子的酰基、胆固醇衍生物、甘油酯、磷脂或鞘磷脂；P 是亲水性聚合物；s 是 1 或 2，t 是 0 或 1，s + t 是 1 或 2；以及 Z1 和 Z2 各自独立地是选定的二价间隔物。
• LIPID DERIVATIVE IN WHICH HYDROPHILIC POLYMER IS BOUND VIA CYCLIC BENZYLIDENE ACETAL LINKERS
  申请人：NOF Corporation

  公开号：EP3357514B1

  公开（公告）日：2021-04-14