盐酸氯卡帕明 | 28058-62-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 中文名称: 盐酸氯卡帕明
• 中文别名: 盐酸氯卡匹帕明；盐酸氯卡比咪嗪
• 英文名称: Clocapramine dihydrochloride
• 英文别名: 1-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-piperidin-1-ylpiperidine-4-carboxamide;dihydrochloride
• CAS: 28058-62-0
• 化学式: C28H39Cl3N4O
• 分子量: 554.0
• InChiKey: UUTRFZNTTSPNOY-UHFFFAOYSA-N

物化性质

• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -4.05
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  55.2
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• STABLE EMULSION COMPOSITION
  申请人：Asakawa Naoki

  公开号：US20100016381A1

  公开（公告）日：2010-01-21

  The present invention provides an emulsion composition comprising (A) a compound stable in an acidic range, and (B) a buffer, wherein the pH is adjusted from about 3.7 to about 5.5.

  本发明提供了一种乳液组合物，包括(A)在酸性范围内稳定的化合物和(B)缓冲剂，其中pH值调节在大约3.7到5.5之间。
• NOVEL AMINES AND THEIR USE
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0424525A1

  公开（公告）日：1991-05-02

  Amines represented by general formula (1) and acid addition salts and quaternary ammonium salts thereof are disclosed. The amines represented by formula (1) or pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof are useful for treatment and prophylaxis of heart diseases of animals, particularly arrhythmia, myocardial infarction, angina pectoris, cardiac failure, etc.

  本发明公开了通式（1）代表的胺及其酸加成盐和季铵盐。由式（1）代表的胺或其药学上可接受的酸加成盐和季铵盐可用于治疗和预防动物的心脏疾病，特别是心律失常、心肌梗塞、心绞痛、心力衰竭等。
• CRYSTALLINE CONDITION DISLOCATING METHOD
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0665009A1

  公开（公告）日：1995-08-02

  An object of this invention is to provide a method of dislocating the crystalline condition of crystalline medicine simply, speedily and homogeneously, and, moreover, in large quantities at once. This invention is directed to a method using an extruder when crystalline medicine in a certain crystalline condition (△ is dislocated to another crystalline condition (○), i.e., when the dislocation of crystalline condition (△->○) is carried out.

  本发明的目的是提供一种简单、快速和均匀地将结晶药物的结晶状态变位的方法，而且是一次性大量变位。本发明针对的是一种使用挤压机将某种结晶状态（△）的结晶药物变位到另一种结晶状态（○）的方法，即结晶状态（△->○）变位的方法。
• METHOD OF MANUFACTURING WAX MATRICES
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0665010A1

  公开（公告）日：1995-08-02

  A method capable of manufacturing wax matrices efficiently in large quantities at once characterized in that a multiscrew extruder is used to achieve the object.

  一种能够一次性大量高效制造蜡基质的方法，其特征在于使用多螺杆挤压机来实现该目标。
• IONTOPHORESIS DEVICE
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP0705619A1

  公开（公告）日：1996-04-10

  To avoid a reduction of the conductivity in iontophoresis due to the electrical decomposition and the changes in chemical properties of the electrodes themselves, covering by an electrical insulator, and to prevent a drop in the transport rate due to ions freed from the electrode. Provision is made of an electrode structure provided integrally with a reversible electrode and an auxiliary electrode for regeneration of the same and a regeneration current conducting means for conducting a current for regeneration of the reversible electrode when the therapeutic current is off, or the invention is comprised of a reversible electrode and an ion exchange membrane difficult for ions freed from that electrode to penetrate.

  为了避免在离子透入疗法中由于电极本身的电分解和化学性质的变化而导致电导率下降，需要用电绝缘体覆盖，并防止由于离子从电极中释放出来而导致传输速率下降。本发明提供了一种电极结构，该电极结构中集成有一个可逆电极和一个用于再生的辅助电极，以及一个再生电流传导装置，用于在治疗电流关闭时传导电流，使可逆电极再生，或者本发明由一个可逆电极和一个离子交换膜组成，从该电极释放的离子难以渗透。