1-(4-chlorobenzyl)-2-((2,2,5,5-d4-pyrrolidin-1-yl)methyl)-1H-benzo[d]imidazole | 1251554-77-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(4-chlorobenzyl)-2-((2,2,5,5-d4-pyrrolidin-1-yl)methyl)-1H-benzo[d]imidazole
• 英文别名: 1-[(4-Chlorophenyl)methyl]-2-[(2,2,5,5-tetradeuteriopyrrolidin-1-yl)methyl]benzimidazole
• CAS: 1251554-77-4
• 化学式: C₁₉H₂₀ClN₃
• 分子量: 329.809
• InChiKey: CJXAEXPPLWQRFR-AREBVXNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  21.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Deuterium Modified Benzimidazoles
  申请人：Persichetti Rose A.

  公开号：US20120058085A1

  公开（公告）日：2012-03-08

  This invention relates to derivatives of 1 -(p-chlorobenzyl)- 2 -( 1 -pyrrolidinylmethyl)benzimidazole according to Formula I wherein at least one Y is deuterium described herein and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of hepatitis C virus (HCV) RNA replication.