2,6-bis(N-furfuryliminomethyl)pyridine | 1449005-15-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-bis(N-furfuryliminomethyl)pyridine
• CAS: 1449005-15-5
• 化学式: C₁₇H₁₅N₃O₂
• 分子量: 293.325
• InChiKey: CPRJLLFCFMXMNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.51
• 重原子数：
  22.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  63.89
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2,6-bis(N-furfuryliminomethyl)pyridine 在 sodium hydroxide 作用下， 以 水 、 甲苯 为溶剂， 生成 2,6-pyridine-bis-N-furfurylaminomethylphosphonic acid
  参考文献：
  名称：

  Stereochemistry of Phosphite Addition to Azomethine Bond of Achiral 2,6-Pyridinedicarbaldimines and Isophthalaldimines—A Comparative Study

  摘要：

  The addition of dialkyl H-phosphonates to isophthalaldimines 1a-d and pyridine-2,6-dicarboxaldimines 2a-d was investigated and led to the corresponding aminophosphonates. Diastereoselectivity of the addition to pyridine-2,6-dicarboxaldimines was lower than to isophthalaldimines. In contrast, addition of bis(trimethylsilyl) H-phosphonate to both groups of aldimines demonstrated that the diastereoselectivity in case of pyridine-2,6-dicarboxaldimines is comparable or even better than that for the isophthalic derivatives.

  DOI：

  10.1080/10426507.2012.718298
• 作为产物：
  描述：

  吡啶-2,6-二甲醛 、 2-呋喃甲胺 以 甲醇 为溶剂， 以83%的产率得到2,6-bis(N-furfuryliminomethyl)pyridine
  参考文献：
  名称：

  Stereochemistry of Phosphite Addition to Azomethine Bond of Achiral 2,6-Pyridinedicarbaldimines and Isophthalaldimines—A Comparative Study

  摘要：

  The addition of dialkyl H-phosphonates to isophthalaldimines 1a-d and pyridine-2,6-dicarboxaldimines 2a-d was investigated and led to the corresponding aminophosphonates. Diastereoselectivity of the addition to pyridine-2,6-dicarboxaldimines was lower than to isophthalaldimines. In contrast, addition of bis(trimethylsilyl) H-phosphonate to both groups of aldimines demonstrated that the diastereoselectivity in case of pyridine-2,6-dicarboxaldimines is comparable or even better than that for the isophthalic derivatives.

  DOI：

  10.1080/10426507.2012.718298