氯己定二盐酸盐杂质B | 1308292-89-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氯己定二盐酸盐杂质B
• 英文名称: Chlorhexidine Impurity B
• 英文别名: [N'-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]carbamimidoyl]urea
• CAS: 1308292-89-8
• 化学式: C₁₆H₂₆ClN₉O
• 分子量: 395.9
• InChiKey: LATUPHDTTULFOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  182
• 氢给体数：
  6
• 氢受体数：
  3

文献信息

• Sterilized chlorhexidine article and method of sterilizing a chlorhexidine article
  申请人：Sage Products, LLC

  公开号：US10188598B1

  公开（公告）日：2019-01-29

  The present disclosure provides a sterilized chlorhexidine product that comprises a package and a sterilized chlorhexidine article. The package defines an interior volume. The sterilized chlorhexidine article comprises a sterilized applicator and a sterilized antiseptic composition. The sterilized antiseptic composition comprises a sterilized solvent and a sterilized antibacterial agent dissolved in the solvent. The sterilized chlorhexidine article is disposed in the internal volume of the package. The sterilized chlorhexidine article has a Sterility Assurance Level of from 10−3 to 10−9. The present disclosure also provides a method for sterilizing the chlorhexidine article.

  本公开提供了一种灭菌洗必泰产品，它包括一个包装和一个灭菌洗必泰物品。包装确定了一个内部容积。灭菌洗必泰物品包括灭菌涂抹器和灭菌消毒组合物。灭菌消毒组合物包括灭菌溶剂和溶解在溶剂中的灭菌抗菌剂。灭菌洗必泰物品放置在包装内部。灭菌洗必泰物品的无菌保证等级为 10-3 到 10-9。本公开还提供了一种对洗必泰物品进行灭菌的方法。
• Systems, methods, and devices for sterilizing antiseptic solutions
  申请人：CAREFUSION 2200, INC.

  公开号：US11027032B2

  公开（公告）日：2021-06-08

  A method for sterilizing an antiseptic solution includes providing a container containing the antiseptic solution, the antiseptic solution having an initial purity, selecting a sterilization temperature from about 85° C. to about 135° C. and an sterilization time from about 1 minute to about 19 hours, heating the antiseptic solution to the selected sterilization temperature, maintaining the temperature for the selected sterilization time, and terminating the heating of the antiseptic solution when the sterilization time expires. After terminating the heating, the antiseptic solution has a post-sterilization purity. The sterilization temperature and the sterilization time are selected such that after terminating the heating, the antiseptic solution is sterile and has a post-sterilization purity of at least about 92% and the percentage point change in purity from the initial purity to the post-sterilization purity is at most about 5%.

  一种消毒杀菌溶液的方法包括提供一个装有消毒杀菌溶液的容器，消毒杀菌溶液具有初始纯度，选择从约85℃到约135℃的消毒杀菌温度和从约1分钟到约19小时的消毒杀菌时间，将消毒杀菌溶液加热到所选的消毒杀菌温度，在所选的消毒杀菌时间内保持该温度，并在消毒杀菌时间结束时终止消毒杀菌溶液的加热。加热结束后，消毒液具有消毒后纯度。灭菌温度和灭菌时间的选择是，在终止加热后，防腐溶液是无菌的，其灭菌后纯度至少约为 92%，从初始纯度到灭菌后纯度的纯度百分点变化最多约为 5%。
• METHOD FOR PREPARING A STERILE ANTISEPTIC SOLUTION
  申请人：CareFusion 2200 Inc.

  公开号：EP3092013B1

  公开（公告）日：2021-06-30
• DI(4-CHLORO-PHENYLDIGUANIDO) DERIVATIVE WHICH IS FREE OF POTENTIAL GENOTOXICITY AND A PROCESS FOR REDUCING THE RESIDUAL AMOUNT OF P-CHLOROANILINE IN SAID DI(4-CHLORO-PHENYLDIGUANIDO) DERIVATIVE
  申请人：Sanchez Salguero Laura

  公开号：US20130065965A1

  公开（公告）日：2013-03-14

  The invention relates to a process for reducing the residual amount of p-chloroaniline in chlorhexidine. Also, the invention relates to a process for preparing chlorhexidine, or a pharmaceutically acceptable salt thereof, which is free of potential genotoxicity. In addition, the invention refers to the said chlorhexidine, or a pharmaceutically acceptable salt thereof, which is free of potential genotoxicity. Further, the invention relates to an analytical HPLC method for the determination of potentially genotoxic impurities in samples of chlorhexidine, or of a pharmaceutically acceptable salt thereof. The invention also relates to stabilized chlorhexidine digluconate salt free of potential genotoxicity in aqueous solution, and to a method for stabilizing chlorhexidine digluconate salt free of potential genotoxicity in aqueous solution.
• SYSTEMS, METHODS, AND DEVICES FOR STERILIZING ANTISEPTIC SOLUTIONS
  申请人：CAREFUSION 2200, INC.

  公开号：US20150190535A1

  公开（公告）日：2015-07-09

  A method for sterilizing an antiseptic solution includes providing a container containing the antiseptic solution, the antiseptic solution having an initial purity, selecting a sterilization temperature from about 85° C. to about 135° C. and an sterilization time from about 1 minute to about 19 hours, heating the antiseptic solution to the selected sterilization temperature, maintaining the temperature for the selected sterilization time, and terminating the heating of the antiseptic solution when the sterilization time expires. After terminating the heating, the antiseptic solution has a post-sterilization purity. The sterilization temperature and the sterilization time are selected such that after terminating the heating, the antiseptic solution is sterile and has a post-sterilization purity of at least about 92% and the percentage point change in purity from the initial purity to the post-sterilization purity is at most about 5%.