2-nitro-4-styrylaniline | 907951-31-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-nitro-4-styrylaniline
• 英文别名: 2-nitro-4-[(E)-2-phenylethenyl]aniline
• CAS: 907951-31-9
• 化学式: C₁₄H₁₂N₂O₂
• 分子量: 240.261
• InChiKey: QYDSEDUGTOHSPQ-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-nitro-4-styrylaniline 在 palladium diacetate 亚硝酸特丁酯 、 2,6-二叔丁基-4-甲基苯酚 、 三氟化硼乙醚 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.75h， 生成 2-nitro-4-styryl-1-(4-vinyl-phenylsulfanyl)-benzene
  参考文献：
  名称：

  Synthesis and testing of new end-functionalized oligomers for molecular electronics

  摘要：

  Several new classes of oligomers have been synthesized with functionalities designed to aid in the understanding of molecular device behavior, specifically when molecules are interfaced between proximal electronic probes. The compounds synthesized are series of azobenzenes, bipyridines and oligo(phenylene vinylene)s that bear acetyl-protected thiols for ultimate attachment to metallic surfaces. Some initial electrochemical and solid-state test results are also reported. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2003.09.004
• 作为产物：
  描述：

  苯乙烯 、 4-碘-2-硝基苯胺 在 palladium diacetate N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 以69%的产率得到2-nitro-4-styrylaniline
  参考文献：
  名称：

  Synthesis and testing of new end-functionalized oligomers for molecular electronics

  摘要：

  Several new classes of oligomers have been synthesized with functionalities designed to aid in the understanding of molecular device behavior, specifically when molecules are interfaced between proximal electronic probes. The compounds synthesized are series of azobenzenes, bipyridines and oligo(phenylene vinylene)s that bear acetyl-protected thiols for ultimate attachment to metallic surfaces. Some initial electrochemical and solid-state test results are also reported. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2003.09.004

文献信息

• Inhibition and Dispersion of Bacterial Biofilms with 2-Aminobenzimidazole Derivatives
  申请人：BLACKWELL Helen

  公开号：US20130136782A1

  公开（公告）日：2013-05-30

  Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.

  本文描述的化合物可以抑制革兰氏阴性细菌的生物膜形成或分散已形成的生物膜。生物膜抑制化合物可以被封装或包含在聚合物基质中以进行控制释放。此外，还提供了包含生物膜抑制化合物的涂层、薄膜、多层薄膜、水凝胶、微球和纳米球，以及含有生物膜抑制化合物的制药组合物和消毒组合物。提供了抑制生物膜形成或分散已形成生物膜的方法。还提供了治疗革兰氏阴性细菌感染的方法，特别是那些形成生物膜的假单胞菌，尤其是P. aeruginosa。
• AGENT FOR CONTROLLING FUNCTION OF GPR34 RECEPTOR
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1849465A1

  公开（公告）日：2007-10-31

  The present invention provides a GPR receptor function regulator comprising the compound represented by the formula: [wherein ring A is an optionally substituted isocyclic or heterocyclic ring, P is a bond or spacer, ring D is an optionally substituted monocyclic aromatic ring which may be condensed with a 5-to 7-membered ring, V is a bond or the group represented by the formula -CR14=CR15 - or - N=CR16- (wherein R14, R15 and R16 each represents a hydrogen atom or optionally substituted hydrocarbon group), Q is a bond or spacer, and W is a carboxyl or a group biologically equivalent to a carboxyl] or its salt or a prodrug thereof

  本发明提供了一种 GPR 受体功能调节剂，包括由式表示的化合物： [其中环A是任选取代的异环或杂环，P是键或间隔物，环D是任选取代的单环芳香环，可与5-7元环缩合，V是键或由式-CR14＝CR15-或-N＝CR16-代表的基团（其中R14、R15 和 R16 各代表一个氢原子或任选取代的烃基），Q 是键或间隔物，W 是羧基或生物等价于羧基的基团]或其盐或其原药
• Inhibition and dispersion of bacterial biofilms with 2-aminobenzimidazole derivatives
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US10292390B2

  公开（公告）日：2019-05-21

  Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.

  本文所述化合物可抑制革兰氏阴性细菌生物膜的形成或驱散已形成的生物膜。生物膜抑制化合物可封装或包含在聚合物基质中，以实现控制释放。此外，还提供了含有生物膜抑制化合物的涂层、薄膜、多层膜、水凝胶、微球和纳米球以及药物组合物和消毒组合物。还提供了抑制生物膜形成或驱散已形成的生物膜的方法。提供了治疗形成生物膜的革兰氏阴性细菌感染的方法，特别是假单胞菌感染，尤其是铜绿假单胞菌感染。
• Regulating Agent of GPR34 Receptor Function
  申请人：Itoh Fumio

  公开号：US20100130737A1

  公开（公告）日：2010-05-27

  The present invention provides a GPR receptor function regulator comprising the compound represented by the formula: [wherein ring A is an optionally substituted isocyclic or heterocyclic ring, P is a bond or spacer, ring D is an optionally substituted monocyclic aromatic ring which may be condensed with a 5- to 7-membered ring, V is a bond or the group represented by the formula —CR 14 ═CR 15 — or —N═CR 16 — (wherein R 14 , R 15 and R 16 each represents a hydrogen atom or optionally substituted hydrocarbon group), Q is a bond or spacer, and W is a carboxyl or a group biologically equivalent to a carboxyl] or its salt or a prodrug thereof.