N,N-dimethyl-2-(4-fluoro-2-nitrophenyloxy)-5-chlorobenzylamine | 951172-92-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-dimethyl-2-(4-fluoro-2-nitrophenyloxy)-5-chlorobenzylamine
• CAS: 951172-92-2
• 化学式: C₁₅H₁₄ClFN₂O₃
• 分子量: 324.739
• InChiKey: FTGQWMBKYBFQSP-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  N,N-dimethyl-2-(4-fluoro-2-nitrophenyloxy)-5-chlorobenzylamine 在 盐酸 、 tin(ll) chloride 作用下， 以 甲醇 为溶剂， 以91%的产率得到2-(4-Chloro-2-((dimethylamino)methyl)phenoxy)-5-fluorobenzenamine
  参考文献：
  名称：

  New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET

  摘要：

  A series of fluorinated diphenylchalcogen derivatives, possessing a sulfur or an oxygen bridge, has been prepared with the aim to get a suitable radiotracer to image the SERT in vivo using positron emission tomography (PET). The compounds were synthesized and assayed toward the serotonin (SERT), dopamine (DAT), and norepinephrine (NET) transporters. Among the developed series, five compounds display a high SERT affinity (K-i: 0.27-2.91 nM range) and can be labeled either with carbon-11 or fluorine-18. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.082
• 作为产物：
  描述：

  N,N-dimethyl-2-(4-fluoro-2-nitrophenyloxy)-5-chlorobenzamide 在 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以73%的产率得到N,N-dimethyl-2-(4-fluoro-2-nitrophenyloxy)-5-chlorobenzylamine
  参考文献：
  名称：

  New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET

  摘要：

  A series of fluorinated diphenylchalcogen derivatives, possessing a sulfur or an oxygen bridge, has been prepared with the aim to get a suitable radiotracer to image the SERT in vivo using positron emission tomography (PET). The compounds were synthesized and assayed toward the serotonin (SERT), dopamine (DAT), and norepinephrine (NET) transporters. Among the developed series, five compounds display a high SERT affinity (K-i: 0.27-2.91 nM range) and can be labeled either with carbon-11 or fluorine-18. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.082