(3aR)-6t-benzyloxycarbonylamino-7c-(2-benzyloxycarbonylamino-O⁴,O⁶-isopropylidene-α-D-ribo-2,3-dideoxy-hexopyranosyloxy)-4c-methoxy-3-methyl-(3ar,7ac)-hexahydro-benzooxazol-2-one | 73488-23-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3aR)-6t-benzyloxycarbonylamino-7c-(2-benzyloxycarbonylamino-O⁴,O⁶-isopropylidene-α-D-ribo-2,3-dideoxy-hexopyranosyloxy)-4c-methoxy-3-methyl-(3ar,7ac)-hexahydro-benzooxazol-2-one
• 英文别名: 1L-1-benzyloxycarbonylamino-O⁶-(2-benzyloxycarbonylamino-O⁴,O⁶-isopropylidene-α-D-ribo-2,3-dideoxy-hexopyranosyl)-4-(carboxy-methyl-amino)-O³-methyl-1,2,4-trideoxy-muco-inositol 4->5-lactone
• CAS: 73488-23-0
• 化学式: C₃₄H₄₃N₃O₁₁
• 分子量: 669.729
• InChiKey: APMJHUZQFIULJI-XFNLJASBSA-N

反应信息

• 作为反应物：
  描述：

  (3aR)-6t-benzyloxycarbonylamino-7c-(2-benzyloxycarbonylamino-O⁴,O⁶-isopropylidene-α-D-ribo-2,3-dideoxy-hexopyranosyloxy)-4c-methoxy-3-methyl-(3ar,7ac)-hexahydro-benzooxazol-2-one 在 吡啶 、 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (3aR)-7c-(6-azido-2-benzyloxycarbonylamino-α-D-ribo-2,3,6-trideoxy-hexopyranosyloxy)-6t-benzyloxycarbonylamino-4c-methoxy-3-methyl-(3ar,7ac)-hexahydro-benzooxazol-2-one
  参考文献：
  名称：

  Syntheses of sporaricin analogues, 2-deoxy-4-N-glycyl-6-O-(.ALPHA.-nebrosaminyl)fortamine and its 3-de-O-methyl compound.

  摘要：

  2-Deoxy-4-N-glycyl-6-O-(α-nebrosaminyl)fortamine (21) and 3-de-O-methyl-2-deoxy-4-N-glycyl-6-O-(α-nebrosaminyl)fortamine (27) were prepared starting from lividamine. The syntheses include four key steps, that is, transformation of 2-deoxystreptamine moiety of lividamine to 4-N, 3-O-didemethyl-2-deoxyfortamine, selective 4-N-methylation of the new aminocyclitol moiety, selective attachment of a glycyl residue to the methylamino group at C-4 and selective amination at C-6'.

  DOI：

  10.7164/antibiotics.32.1137
• 作为产物：
  描述：

  (3aR)-6t-benzyloxycarbonylamino-7c-(2-benzyloxycarbonylamino-O⁴,O⁶-isopropylidene-α-D-ribo-2,3-dideoxy-hexopyranosyloxy)-4c-hydroxy-(3ar,7ac)-hexahydro-benzooxazol-2-one 、 碘甲烷 在 barium dihydroxide 、 barium(II) oxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (3aR)-6t-benzyloxycarbonylamino-7c-(2-benzyloxycarbonylamino-O⁴,O⁶-isopropylidene-α-D-ribo-2,3-dideoxy-hexopyranosyloxy)-4c-methoxy-3-methyl-(3ar,7ac)-hexahydro-benzooxazol-2-one
  参考文献：
  名称：

  Syntheses of sporaricin analogues, 2-deoxy-4-N-glycyl-6-O-(.ALPHA.-nebrosaminyl)fortamine and its 3-de-O-methyl compound.

  摘要：

  2-Deoxy-4-N-glycyl-6-O-(α-nebrosaminyl)fortamine (21) and 3-de-O-methyl-2-deoxy-4-N-glycyl-6-O-(α-nebrosaminyl)fortamine (27) were prepared starting from lividamine. The syntheses include four key steps, that is, transformation of 2-deoxystreptamine moiety of lividamine to 4-N, 3-O-didemethyl-2-deoxyfortamine, selective 4-N-methylation of the new aminocyclitol moiety, selective attachment of a glycyl residue to the methylamino group at C-4 and selective amination at C-6'.

  DOI：

  10.7164/antibiotics.32.1137