2,5-dibromo-2,5-dimethyl-hex-3-ene | 90154-62-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: 2,5-dibromo-2,5-dimethyl-hex-3-ene
• 英文别名: 2,5-Dibrom-2,5-dimethyl-hex-3-en；2.5-Dimethyl-2.5-dibrom-hexen-(3)；2,5-Dibromo-2,5-dimethylhex-3-ene
• CAS: 90154-62-4
• 化学式: C₈H₁₄Br₂
• 分子量: 270.007
• InChiKey: NGYCIYWLHWDPLX-UHFFFAOYSA-N

物化性质

• 沸点：
  245.1±20.0 °C(Predicted)
• 密度：
  1.494±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2,5-dibromo-2,5-dimethyl-hex-3-ene 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 生成 (2,5-Dimethyl-hexadien-2,4-yl-3)-malonsaeure
  参考文献：
  名称：

  Korte,F. et al., Justus Liebigs Annalen der Chemie, 1963, vol. 664, p. 97 - 113

  摘要：

  DOI：
• 作为产物：
  描述：

  2,5-二甲基-2,4-己二烯 在 溴 作用下， 生成 2,5-dibromo-2,5-dimethyl-hex-3-ene
  参考文献：
  名称：

  末端叔丁基化聚烯烃的化学行为。

  摘要：

  已经研究了各种低聚物2的化学行为。二烯3的催化加氢产生单烯4。三烯7加氢成二烯8，单烯9和饱和烃10。向3和7中溴加成分别生成二溴化物17和18，即，低聚烯烃体系在其上受到攻击。末端烯烃碳原子。类似地，当使用少于1当量的溴时，高级乙烯基化合物19和20分别产生1，8-和1，10-溴加成物23和24。用过量的溴处理四烯19提供四溴化物25。在环氧化反应中，与间氯过苯甲酸（MCPBA）和二甲基二环氧乙烷（DMDO）一起研究了两种低聚模型：三烯7和四烯19。而7则为重排产物31提供了MCPBA。 ，得到带有DMDO的对称环氧化物32。类似地，用MCPBA将19转化为单环氧化物33，用DMDO转化为34。没有与N-苯基三唑啉二酮（PTAD）进行Diels-Alder加成7。将共轭π-体系扩展至下一个更高的乙烯基，19，以良好的收率将NPTD加到对称加合物37上。在向戊烯20和己烯21中添加NPTD

  DOI：

  10.3762/bjoc.11.139

文献信息

• Indocyanine green enhanced transpupillary thermotherapy of circumscribed choroidal haemangioma
  作者：A Kamal、A R Watts、I G Rennie

  DOI：10.1038/eye.2000.187

  日期：2000.9

  Purpose To investigate the effect of indocyanine green in enhancing the effect of diode laser for treatment of circumscribed choroidal haemangioma. Methods Intravenous indocyanine green was used to enhance uptake of heat energy during transpupillary diode thermotherapy of circumscribed choroidal haemangioma. Results In a series of 6 patients treated in this manner, response to treatment was much improved compared with results without the use of indocyanine green. All patients retained the same or better visual acuity after treatment, and 67% of eyes improved visual acuity by more than 2 lines on Snellen testing. Ultrasonographic and angiographic evidence of improvement was seen in all patients. Treatment complications were minimal, comprising transient worsening of preexisting cystoid macular oedema in one case, and a small macular branch vein occlusion in the retina overlying the treated area. Conclusions The use of indocyanine green as a contrast medium during transpupillary thermotherapy allows consistent uptake of diode laser energy, and shortens the duration of laser burn required. It is a cost-effective, easily performed outpatient procedure, with lower morbidity than other treatment modalities.

  目的 研究吲哚青绿在增强二极管激光治疗限局性脉络膜血管瘤效果中的作用。方法 使用静脉注射吲哚青绿，以增强在限局性脉络膜血管瘤的瞳孔透过二极管热疗过程中热能的吸收。结果 在以这种方式治疗的6名患者中，与未使用吲哚青绿的结果相比，治疗反应显著改善。所有患者在治疗后视觉敏锐度保持不变或有所提高，67%的眼睛在Snellen测试中视觉敏锐度提高超过2行。所有患者均观察到超声波和血管造影证据显示改善。治疗并发症很少，仅包括1例已有囊性黄斑水肿的暂时恶化，以及在治疗区域上方视网膜的小黄斑分支静脉阻塞。结论 在瞳孔透过热疗中使用吲哚青绿作为对比剂，可确保二极管激光能量的有效吸收，缩短所需的激光烧灼时间。这是一种成本效益高、易于进行的门诊程序，其发病率低于其他治疗方式。
• Compliance and viewpoint of glaucoma patients in Greece
  作者：A G P Konstas、G Maskaleris、S Gratsonidis、C Sardelli

  DOI：10.1038/eye.2000.197

  日期：2000.9

  Purpose To document the prevalence of non-compliance and to investigate patients perceptions concerning glaucoma in a Greek cohort. Methods We investigated 100 consecutive patients referred to our glaucoma clinic and already treated for chronic glaucoma. Compliance and patients insight were ascertained by two independent observers by means of a predetermined questionnaire. All patients were subsequently assessed for their ability to instil their eyedrops accurately. Results Fifty one per cent of our patients were not aware of the nature of glaucoma, but 80% were afraid it might lead to blindness. Clinically significant non-compliance (more than two doses missed per week) was established in 44% of our patients. Men and those using eyedrops more than 4 times a day were more likely to default. Non-compliant patients exhibited higher mean intraocular pressure (22.9 vs 18.5 mmHg; p > 0.001) and worse visual field loss (10.8 vs 7.0 dB; p = 0.008) compared with compliant patients. Involuntary non-compliance was also common in our group, with only 53% instilling their eye drops accurately. Conclusion Non-compliance is a significant limiting factor in glaucoma therapy in Greece.

  目的 记录不遵医嘱的普遍程度，并调查希腊患者群体对青光眼的认知。方法 我们调查了100名转诊至青光眼诊所并已接受慢性青光眼治疗的连续患者。两名独立观察员通过预先设计的问卷调查表确定患者遵医嘱情况和认知。随后对所有患者进行准确滴眼液能力的评估。结果 51%的患者不了解青光眼的性质，但80%的患者担心青光眼会导致失明。44%的患者存在临床意义的不遵医嘱情况（每周漏滴两次以上）。男性和每天使用滴眼液超过4次的患者更可能不遵医嘱。与遵医嘱的患者相比，不遵医嘱的患者眼压平均值更高（22.9 vs 18.5 mmHg；p > 0.001），视野丧失更严重（10.8 vs 7.0 dB；p = 0.008）。非自愿不遵医嘱在我们的患者群体中也很常见，只有53%的患者能够准确滴眼液。结论 不遵医嘱是希腊青光眼治疗中一个重要的限制因素。
• Salkind; Sabojew, Chemische Berichte, 1929, vol. 62, p. 2173
  作者：Salkind、Sabojew

  DOI：——

  日期：——