[Pt(2-(2-pyridyl)-dipyrido-[3,2-a:2',3'-c]-phenazine)Cl]Cl | 1415337-80-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: [Pt(2-(2-pyridyl)-dipyrido-[3,2-a:2',3'-c]-phenazine)Cl]Cl
• 英文别名: [Pt(pydppz)Cl]Cl
• CAS: 1415337-80-2
• 化学式: C₂₃H₁₃ClN₅Pt*Cl
• 分子量: 625.376
• InChiKey: QEZKTGNZWCQSHG-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Pt(2-(2-pyridyl)-dipyrido-[3,2-a:2',3'-c]-phenazine)Cl]Cl 、 ferrocenyl acetylene 在 三乙胺 、 copper(l) iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.5h， 生成 [Pt(pydppz)(CCFc)]Cl
  参考文献：
  名称：

  Photo-induced anticancer activity of polypyridyl platinum(II) complexes

  摘要：

  Polypyridyl platinum(II) complexes (1-5), viz., [Pt(pyphen)Cl]Cl (1), [Pt(pyphen)(C CFc)]Cl (2), [Pt(pydppz)Cl]Cl (3), [Pt(pydppz)(C CPh)]Cl (4) and [Pt(pydppz)(C CFc)]Cl (5), where pyphen is 6-(2-pyridyl)-1,10-phenanthroline, pydppz is 6-(2-pyridyl)-dipyrido-[3,2-a:2',3'-c]-phenazine, FcC CH is ferrocenyl acetylene and PhC CH is phenyl acetylene, were synthesized, characterized and their DNA binding and photocytotoxic properties studied. The complexes showed strong binding affinity to calf-thymus DNA giving K-app of similar to 10(6)-10(7) M-1. Complexes 4 and 5 showed dual mode of binding to ct-DNA. The pydppz complexes 3-5 having a photoactive phenazine moiety showed photocytotoxicity in HeLa and MCF-7 cells in UV-A light of 365 nm with apoptotic cell death as evidenced from the acridine orange/ethidium bromide dual staining and the FACS data. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.09.025
• 作为产物：
  描述：

  dichloro( 1,5-cyclooctadiene)platinum(ll) 、 3-(pyridin-2-yl)dipyrido[3,2-a:2’,3’-c]phenazine 以 四氢呋喃 、 水 为溶剂， 反应 3.0h， 以70%的产率得到[Pt(2-(2-pyridyl)-dipyrido-[3,2-a:2',3'-c]-phenazine)Cl]Cl
  参考文献：
  名称：

  Photo-induced anticancer activity of polypyridyl platinum(II) complexes

  摘要：

  Polypyridyl platinum(II) complexes (1-5), viz., [Pt(pyphen)Cl]Cl (1), [Pt(pyphen)(C CFc)]Cl (2), [Pt(pydppz)Cl]Cl (3), [Pt(pydppz)(C CPh)]Cl (4) and [Pt(pydppz)(C CFc)]Cl (5), where pyphen is 6-(2-pyridyl)-1,10-phenanthroline, pydppz is 6-(2-pyridyl)-dipyrido-[3,2-a:2',3'-c]-phenazine, FcC CH is ferrocenyl acetylene and PhC CH is phenyl acetylene, were synthesized, characterized and their DNA binding and photocytotoxic properties studied. The complexes showed strong binding affinity to calf-thymus DNA giving K-app of similar to 10(6)-10(7) M-1. Complexes 4 and 5 showed dual mode of binding to ct-DNA. The pydppz complexes 3-5 having a photoactive phenazine moiety showed photocytotoxicity in HeLa and MCF-7 cells in UV-A light of 365 nm with apoptotic cell death as evidenced from the acridine orange/ethidium bromide dual staining and the FACS data. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.09.025