2-[5-(Acetamidomethyl)-2-chlorophenylamino]-N-cyclohexylmethyl-1-methylbenzimidazole-5-carboxamide | 1242268-99-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[5-(Acetamidomethyl)-2-chlorophenylamino]-N-cyclohexylmethyl-1-methylbenzimidazole-5-carboxamide
• 英文别名: 2-[5-(acetamidomethyl)-2-chloroanilino]-N-(cyclohexylmethyl)-1-methylbenzimidazole-5-carboxamide
• CAS: 1242268-99-0
• 化学式: C₂₅H₃₀ClN₅O₂
• 分子量: 467.998
• InChiKey: VGLKQMABFPKKLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  88
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• NEW COMPOUNDS
  申请人：PFAU Roland

  公开号：US20120196897A1

  公开（公告）日：2012-08-02

  The present invention relates to compounds of general formula I in which A, L, M, Q 2 , Q 3 , Q 4 , R 1 , R 5 , R a , R b , R c , W, X, Y, Z 1 , Z 2 , Z 3 are defined in the description, the salts thereof, particularly the physiologically acceptable salts thereof. The compounds are of potential utility in the treatment and/or prevention of inflammatory diseases and associated conditions, in particular, in the treatment and/or prevention of pain. The invention also relates to the use of such compounds as medicaments, to pharmaceutical compositions containing them, and to their preparation.

  本发明涉及一般式I的化合物，其中A，L，M，Q2，Q3，Q4，R1，R5，Ra，Rb，Rc，W，X，Y，Z1，Z2，Z3在描述中定义，其盐，特别是其生理上可接受的盐。这些化合物在治疗和/或预防炎症性疾病和相关病症方面具有潜在的用途，特别是在治疗和/或预防疼痛方面。本发明还涉及将这些化合物用作药物、包含它们的制药组合物以及它们的制备。
• METHODS OF TREATING DISEASES CHARACTERISED BY VASOCONSTRICTION
  申请人：GESYNTA PHARMA AB

  公开号：US20190038603A1

  公开（公告）日：2019-02-07

  There is herein provided a compound that is an mPGES-1 inhibitor, or a prodrug thereof, for use in the treatment or prophylaxis of a disease or disorder characterised by vasoconstriction.
• US8921405B2
  申请人：——

  公开号：US8921405B2

  公开（公告）日：2014-12-30