(2-bromo-4,5-dihydroxyphenyl)(3,4-dihydroxyphenyl) ether | 1257414-25-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-bromo-4,5-dihydroxyphenyl)(3,4-dihydroxyphenyl) ether
• 英文别名: (2-Bromo-4,5-dihydroxyphenyl)(3,4-dihydroxyphenyl)ether；4-bromo-5-(3,4-dihydroxyphenoxy)benzene-1,2-diol
• CAS: 1257414-25-7
• 化学式: C₁₂H₉BrO₅
• 分子量: 313.104
• InChiKey: PIMIKPXOETZORZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,3',4,4'-tetrahydroxydiphenyl ether 在 溴 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以56%的产率得到bis(2-bromo-4,5-dihydroxyphenyl) ether
  参考文献：
  名称：

  Bromophenols as Candida albicans isocitrate lyase inhibitors

  摘要：

  A new series of bromophenols was synthesized by reactions of corresponding phenol analogs with bromine. The synthesized compounds were tested for inhibitory activity against isocitrate lyase (ICL) of Candida albicans and antimicrobial activity against Gram-positive and, Gram-negative bacteria and fungi. Among the synthesized bromophenols, bis(3-bromo-4,5-dihydroxyphenyl)methanone (11) and (3-bromo-4,5-dihydroxyphenyl)(2,3-dibromo-4,5-dihydroxyphenyl)methanone (12) displayed potent inhibitory activities against ICL, showing a stronger inhibitory effects than were found with natural bromophenol 1. The preliminary structure-activity relationships were investigated in order to determine the essential structural requirements for the inhibitory activities of these compounds against ICL of C. albicans. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.09.015

文献信息

• HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE
  申请人：Institute For Applied Cancer Science/The University of Texas MD Anderson Cancer Center

  公开号：US20140066424A1

  公开（公告）日：2014-03-06

  The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.

  本发明涉及化合物和方法，可用作HIF通路活性的抑制剂，用于治疗或预防癌症和其他缺氧介导的疾病。
• METHOD FOR PREPARING POLYMER AND POLYMER PREPARED THEREBY
  申请人：LG Chem, Ltd.

  公开号：EP2857425A1

  公开（公告）日：2015-04-08

  Provided is a method for preparing polymer. By additionally inputting a catalyst reducing agent that reduces an inactivated metal complex compound catalyst to an activated metal complex compound catalyst, a polymer polymerized at a high conversion ratio of a monomer can be provided.

  本发明提供了一种制备聚合物的方法。通过额外输入一种催化剂还原剂，将失活的金属络合物催化剂还原成活化的金属络合物催化剂，可以提供一种以高单体转化率聚合的聚合物。
• Heterocyclic modulators of HIF activity for treatment of disease
  申请人：Board of Regents, University of Texas System

  公开号：US10208059B2

  公开（公告）日：2019-02-19

  The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.

  本发明涉及可作为 HIF 通路活性抑制剂用于治疗或预防癌症和其他缺氧介导的疾病的化合物和方法。
• POLYMER PREPARING METHOD AND POLYMER PREPARED BY THE SAME
  申请人：LG CHEM, LTD.

  公开号：US20140066573A1

  公开（公告）日：2014-03-06

  Provided is a polymer preparing method. By additionally inputting a catalytic reducing agent that reduces an inactivated metal complex compound catalyst to an activated metal complex compound catalyst, a polymer polymerized at a high conversion ratio of a monomer can be provided.
• MULTI-BLOCK COPOLYMER
  申请人：LG CHEM, LTD.

  公开号：US20140375934A1

  公开（公告）日：2014-12-25

  Provided are a multi-block copolymer, a pressure-sensitive adhesive composition, a method of preparing a multi-block copolymer, a pressure-sensitive adhesive polarizing plate, and a liquid crystal display device. The pressure-sensitive adhesive composition including the multi-block copolymer may have excellent durability regardless of a temperature and/or humidity. In addition, the method of preparing a multi-block copolymer may prepare a multi-block copolymer increased in molecular weight which is structurally controlled with a simple process using a compound containing at least two halogen atoms. Accordingly, when included in a pressure-sensitive adhesive resin, the multi-block copolymer may have excellent cohesive strength in the resin, and a network structure during curing, and thus, when applied to a pressure-sensitive adhesive composition, the multi-block copolymer may be usefully applied to an optical member due to excellent durability regardless of a temperature and humidity.