6-(5-N,N-dimethylaminobenzimidazol-2-ylthio)-N-(2,6-diisopropylphenyl)hexanamide | 213685-20-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 6-(5-N,N-dimethylaminobenzimidazol-2-ylthio)-N-(2,6-diisopropylphenyl)hexanamide
• 英文别名: 6-[[6-(dimethylamino)-1H-benzimidazol-2-yl]sulfanyl]-N-[2,6-di(propan-2-yl)phenyl]hexanamide
• CAS: 213685-20-2
• 化学式: C₂₇H₃₈N₄OS
• 分子量: 466.691
• InChiKey: DLQCASWHOGZZCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  86.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• EP1427408A4
  申请人：——

  公开号：EP1427408A4

  公开（公告）日：2005-10-26
• CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$g(a) CONVERTING ENZYME (TACE)
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP1427408A2

  公开（公告）日：2004-06-16
• [EN] CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF- alpha CONVERTING ENZYME (TACE)<br/>[FR] ACIDES HYDROXAMIQUES CYCLIQUES UTILISES COMME INHIBITEURS DE METALLOPROTEINASES MATRICIELLES ET/OU D'ENZYME DE CONVERSION DU TNF- DOLLAR G(A) (TACE)
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2003024899A2

  公开（公告）日：2003-03-27

  The present application describes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from 0, N, NR1, and S(O)¿p?, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP) , TNF-a converting enzyme (TACE) , aggrecanase or a combination thereof, pharmaceutical compositions containing the same, and methods of using the same.