(2S)-2-[4-(benzoylamino)benzyl]-N,N-diethyl-N’-(2-naphthylsulfonyl)malonamide | 1094195-46-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-[4-(benzoylamino)benzyl]-N,N-diethyl-N’-(2-naphthylsulfonyl)malonamide
• 英文别名: (2S)-2-[4-(benzoylamino)benzyl]-N,N-diethyl-N'-(2-naphthylsulfonyl)malonamide；(2S)-2-[(4-benzamidophenyl)methyl]-N,N-diethyl-N'-naphthalen-2-ylsulfonylpropanediamide
• CAS: 1094195-46-6
• 化学式: C₃₁H₃₁N₃O₅S
• 分子量: 557.67
• InChiKey: BMRQCJIAZALUKN-MUUNZHRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2S)-2-(4-aminobenzyl)-N, N-diethyl-N'-(2-naphthylsulfonyl)malonamide 、 苯甲酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 17.0h， 生成 (2S)-2-[4-(benzoylamino)benzyl]-N,N-diethyl-N’-(2-naphthylsulfonyl)malonamide
  参考文献：
  名称：

  NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

  摘要：

  公开号：

  EP2172450B9

文献信息

• MEDICINE FOR SUPPRESSING MALIGNANT TUMOR METASTASIS
  申请人：National Cerebral and Cardiovascular Center

  公开号：EP3127554A1

  公开（公告）日：2017-02-08

  Provided are a novel medicament for suppressing or preventing the metastasis of a malignant tumor such as carcinoma, a novel treatment or prevention method for suppressing or preventing the metastasis of a malignant tumor, etc. The medicament comprises a non-peptidic angiotensin type 2 receptor agonist as an active ingredient. In the medicament, the non-peptidic angiotensin type 2 receptor agonist may be, for example, a sulfonyl malonamide compound. The medicament may be a medicament for use in combination with an anticancer agent and/or an antitumor agent.

  本文提供了一种用于抑制或预防癌等恶性肿瘤转移的新型药物、一种用于抑制或预防恶性肿瘤转移的新型治疗或预防方法等。该药物包括作为活性成分的非肽类血管紧张素 2 型受体激动剂。在该药物中，非肽类血管紧张素 2 型受体激动剂可以是磺酰丙二酰胺化合物等。该药物可以是与抗癌剂和/或抗肿瘤剂联合使用的药物。
• Medicament for suppressing malignant tumor metastasis
  申请人：NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER

  公开号：US10071099B2

  公开（公告）日：2018-09-11

  Provided are a novel medicament for suppressing or preventing the metastasis of a malignant tumor such as carcinoma, a novel treatment or prevention method for suppressing or preventing the metastasis of a malignant tumor, etc. The medicament comprises a non-peptidic angiotensin type 2 receptor agonist as an active ingredient. In the medicament, the non-peptidic angiotensin type 2 receptor agonist may be, for example, a sulfonyl malonamide compound. The medicament may be a medicament for use in combination with an anticancer agent and/or an antitumor agent.

  本文提供了一种用于抑制或预防癌等恶性肿瘤转移的新型药物、一种用于抑制或预防恶性肿瘤转移的新型治疗或预防方法等。该药物包括作为活性成分的非肽类血管紧张素 2 型受体激动剂。在该药物中，非肽类血管紧张素 2 型受体激动剂可以是磺酰丙二酰胺化合物等。该药物可以是与抗癌剂和/或抗肿瘤剂联合使用的药物。
• MEDICAMENT FOR SUPPRESSING MALIGNANT TUMOR METASTASIS
  申请人：NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER

  公开号：US20170014419A1

  公开（公告）日：2017-01-19

  Provided are a novel medicament for suppressing or preventing the metastasis of a malignant tumor such as carcinoma, a novel treatment or prevention method for suppressing or preventing the metastasis of a malignant tumor, etc. The medicament comprises a non-peptidic angiotensin type 2 receptor agonist as an active ingredient. In the medicament, the non-peptidic angiotensin type 2 receptor agonist may be, for example, a sulfonyl malonamide compound. The medicament may be a medicament for use in combination with an anticancer agent and/or an antitumor agent.
• MEDICAMENT FOR PREVENTING OR INHIBITING ACUTE KIDNEY INJURY
  申请人：National Cerebral and Cardiovascular Center

  公开号：US20180280326A1

  公开（公告）日：2018-10-04

  The present invention provides a novel medicament for preventing or inhibiting acute kidney injury, the medicament comprising, as an active ingredient, an angiotensin II receptor type 2 agonist or a pharmacologically acceptable salt thereof, and being used for treatment or prevention of acute kidney injury. Also, the present invention provides a novel method for preventing or inhibiting acute kidney injury, the method comprising administering, to a patient, an effective amount of an angiotensin II receptor type 2 agonist or a pharmacologically acceptable salt thereof in combination with an anticancer agent and/or an antitumor agent.
• US8461209B2
  申请人：——

  公开号：US8461209B2

  公开（公告）日：2013-06-11