6-[2-(R)-[2-(S)-hydroxy-3-(4-hydroxy-3-methanesulfonamidophenoxy)propylamino]propyl]-2,3-dihydro-1,4-benzodioxine-2-(R)-carboxylic acid | 400051-92-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-[2-(R)-[2-(S)-hydroxy-3-(4-hydroxy-3-methanesulfonamidophenoxy)propylamino]propyl]-2,3-dihydro-1,4-benzodioxine-2-(R)-carboxylic acid
• 英文别名: (2R)-6-[(2R)-2-[[(2S)-2-hydroxy-3-[4-hydroxy-3-(methanesulfonamido)phenoxy]propyl]amino]propyl]-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid
• CAS: 400051-92-5
• 化学式: C₂₂H₂₈N₂O₉S
• 分子量: 496.538
• InChiKey: CXPPRJXXKCLYDX-VWVPQACVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  172
• 氢给体数：
  5
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  6-[2-(R)-[2-(S)-hydroxy-3-[3-methanesulfonamido-4-(methoxymethoxy)phenoxy]propylamino]propyl]-2,3-dihydro-1,4-benzodioxine-2-(R)-carboxylic acid ethyl ester 在 盐酸 、 sodium carbonate 作用下， 以 水 为溶剂， 反应 3.0h， 以62%的产率得到6-[2-(R)-[2-(S)-hydroxy-3-(4-hydroxy-3-methanesulfonamidophenoxy)propylamino]propyl]-2,3-dihydro-1,4-benzodioxine-2-(R)-carboxylic acid
  参考文献：
  名称：

  EP1426370

  摘要：

  公开号：

文献信息

• Propanolamine derivative having 1, 4-Benzodioxane ring
  申请人：——

  公开号：US20040235921A1

  公开（公告）日：2004-11-25

  This invention relates to a medicament containing as an active ingredient, a novel propanolamine having a 1,4-benzodioxane ring or a pharmaceutically acceptable salt thereof: 1 The present compound is represented by the above formula wherein R 1-3 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxy group, a (C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkoxy group, a (C 1 -C 6 )alkylsulfonamido group, or a phenyl group; R 4-5 each represents a hydrogen atom or a (C 1 -C 6 )alkyl group; and A represents any of a benzene ring, a pyridine ring and a pyrimidine ring. This compound is useful as a prophylactic or therapeutic agent for diabetes, obesity, hyperlipemia, depression, a respiratory disease, or a gastrointestinal disease.

  本发明涉及一种药物，其作为活性成分含有一种新型的丙醇胺，其具有1,4-苯并二氧杂环环或其药学上可接受的盐：1。该化合物的化学式如上所示，其中R1-3可以相同或不同，每个代表氢原子、卤原子、羟基、（C1-C6）烷基、（C1-C6）烷氧基、（C1-C6）烷基磺酰胺基或苯基；R4-5每个代表氢原子或（C1-C6）烷基；A代表苯环、吡啶环和嘧啶环之一。该化合物可用作糖尿病、肥胖症、高脂血症、抑郁症、呼吸道疾病或胃肠道疾病的预防或治疗剂。
• Propanolamine derivative having 1, 4-benzodioxane ring
  申请人：Nisshin Pharma Inc.

  公开号：US07022732B2

  公开（公告）日：2006-04-04

  This invention relates to a medicament containing as an active ingredient, a novel propanolamine having a 1,4-benzodioxane ring or a pharmaceutically acceptable salt thereof: The present compound is represented by the above formula wherein R1-3 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxy group, a (C1–C6)alkyl group, a (C1–C6)alkoxy group, a (C1–C6)alkylsulfonamido group, or a phenyl group; R4-5 each represents a hydrogen atom or a (C1–C6)alkyl group; and A represents any of a benzene ring, a pyridine ring and a pyrimidine ring. This compound is useful as a prophylactic or therapeutic agent for diabetes, obesity, hyperlipemia, depression, a respiratory disease, or a gastrointestinal disease.

  本发明涉及一种药物，其含有一种新型的丙醇胺作为活性成分，该丙醇胺具有1,4-苯并二氧杂环环或其药学上可接受的盐：所述化合物由上述公式表示，其中R1-3可能相同或不同，且每个代表氢原子、卤素原子、羟基、(C1-C6)烷基、(C1-C6)烷氧基、(C1-C6)烷基磺酰胺基或苯基；R4-5各自代表氢原子或(C1-C6)烷基；A代表苯环、吡啶环和嘧啶环中的任何一种。该化合物可用作预防或治疗糖尿病、肥胖症、高脂血症、抑郁症、呼吸系统疾病或消化系统疾病的药物。
• PROPANOLAMINE DERIVATIVE HAVING 1,4 BENZODIOXANE RING
  申请人：Nisshin Pharma Inc.

  公开号：EP1426370A1

  公开（公告）日：2004-06-09

  This invention relates to a medicament containing as an active ingredient, a novel propanolamine having a 1,4-benzodioxane ring or a pharmaceutically acceptable salt thereof: The present compound is represented by the above formula wherein R1-3 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxy group, a (C1-C6) alkyl group, a (C1-C6)alkoxy group, a (C1-C6)alkylsulfonamido group, or a phenyl group; R4-5 each represents a hydrogen atom or a (C1-C6)alkyl group; and A represents any of a benzene ring, a pyridine ring and a pyrimidine ring. This compound is useful as a prophylactic or therapeutic agent for diabetes, obesity, hyperlipemia, depression, a respiratory disease, or a gastrointestinal disease.

  本发明涉及一种药物，其活性成分是一种具有 1，4-苯并二恶烷环的新型丙醇胺或其药学上可接受的盐： 本发明化合物由上式表示，其中R1-3可以相同或不同，各自代表氢原子、卤素原子、羟基、(C1-C6)烷基、(C1-C6)烷氧基、(C1-C6)烷基磺酰胺基或苯基；R4-5各自代表氢原子或(C1-C6)烷基；A代表苯环、吡啶环和嘧啶环中的任何一种。 该化合物可用作糖尿病、肥胖症、高脂血症、抑郁症、呼吸系统疾病或胃肠道疾病的预防或治疗药物。
• US7022732B2
  申请人：——

  公开号：US7022732B2

  公开（公告）日：2006-04-04