2-Oleoylaminophenol | 201858-32-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Oleoylaminophenol
• 英文别名: (Z)-N-(2-hydroxyphenyl)octadec-9-enamide
• CAS: 201858-32-4
• 化学式: C₂₄H₃₉NO₂
• 分子量: 373.579
• InChiKey: CTRBNBZLLPSOLC-KTKRTIGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  27
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Oleoylaminophenol 、 3-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino)propionic Acid 、 N,N'-二环己基碳二亚胺 在 4-二甲氨基吡啶 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以to obtain 445 mg of the title compound (yield: 72%)的产率得到2-(Oleoylamino)phenyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate
  参考文献：
  名称：

  Pantothenic acid derivatives

  摘要：

  下列一般式（I）所代表的化合物 ##STR1## 其中，R.sup.1和R.sup.2相同或不同，分别代表氢原子或羟基的保护基团；R.sup.3代表饱和或不饱和、线性、支链或环状、单价的C.sub.5 .about.C.sub.25脂肪烃基，可以用芳香族基取代，或者是公式 ##STR2## 中的基团，其中R.sup.4代表饱和或不饱和、线性、支链或环状、单价的C.sub.5 .about.C.sub.25脂肪烃基，可以用芳香族基取代，而R.sup.5代表氢原子，或者是饱和或不饱和、线性、支链或环状、单价的烃基，可以用芳香族基取代；Q代表（a）公式--X.sup.1--A--Y.sup.1--中的基团，其中A代表饱和或不饱和、线性、支链或环状的二价C.sub.2 .about.C.sub.16脂肪烃基，可以用芳香族基、二价芳香族烃基或二价芳香族杂环基取代；X.sup.1和Y.sup.1中的一个代表 ##STR3## 另一个代表--O--、--S--或 ##STR4## 其中R.sup.6和R.sup.7各自代表氢原子或较低的烷基；（b）公式--X.sup.2--(CH.sub.2).sub.l--Y.sup.2--中的基团，其中X.sup.2和Y.sup.2中的一个代表公式 ##STR5## 另一个代表--O--、--S--或 ##STR6## 其中 ##STR7## 代表4.约7个成员的二价含氮芳香杂环基，而R.sup.6与上述定义相同，l为0、1或2；或（c）公式 ##STR8## 中的基团，其中m为2或3；n为1到4的整数。这些化合物对酰基辅酶A胆固醇酰转移酶具有出色的抑制活性。

  公开号：

  US05120738A1
• 作为产物：
  描述：

  油酸 、 2-氨基苯酚 、 N,N'-二环己基碳二亚胺 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以45%的产率得到2-Oleoylaminophenol
  参考文献：
  名称：

  A facile, one-pot synthesis, characterization and antimicrobial activity of o-hydroxy anilide derivatives and 1-substituted-1,3-dicyclohexylurea analogs of long chain carboxylic acids

  摘要：

  A series of novel o-hydroxy anilide derivatives and 1-substituted-1,3-dicyclohexylurea analogs of long chain carboxylic acids have been synthesized. The structures of the synthesized compounds were elucidated by IR, H-1 NMR, C-13 NMR and mass spectral data. All the synthesized compounds were tested for their antimicrobial activity by disk diffusion assay with slight modifications against Gram-positive, Gram-negative strains of bacteria as well as fungal strains. After that mini mum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs) and minimum fungicidal concentrations (MFCs) of all the synthesized compounds were determined. The investigation of antimicrobial screening data revealed that all the tested compounds showed moderate to good microbial inhibitions. Compounds 3e, 4e, 3f and 4f were found to be the most potent antimicrobial agents. (c) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.01.070

文献信息

• US5120738A
  申请人：——

  公开号：US5120738A

  公开（公告）日：1992-06-09
• Pantothenic acid derivatives
  申请人：FUJIREBIO INC.

  公开号：EP0421441B1

  公开（公告）日：1995-01-25
• A facile, one-pot synthesis, characterization and antimicrobial activity of o-hydroxy anilide derivatives and 1-substituted-1,3-dicyclohexylurea analogs of long chain carboxylic acids
  作者：Nida N. Farshori、Anis Ahmad、Asad U. Khan、Abdul Rauf

  DOI：10.1016/j.ejmech.2011.01.070

  日期：2011.4

  A series of novel o-hydroxy anilide derivatives and 1-substituted-1,3-dicyclohexylurea analogs of long chain carboxylic acids have been synthesized. The structures of the synthesized compounds were elucidated by IR, H-1 NMR, C-13 NMR and mass spectral data. All the synthesized compounds were tested for their antimicrobial activity by disk diffusion assay with slight modifications against Gram-positive, Gram-negative strains of bacteria as well as fungal strains. After that mini mum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs) and minimum fungicidal concentrations (MFCs) of all the synthesized compounds were determined. The investigation of antimicrobial screening data revealed that all the tested compounds showed moderate to good microbial inhibitions. Compounds 3e, 4e, 3f and 4f were found to be the most potent antimicrobial agents. (c) 2011 Elsevier Masson SAS. All rights reserved.