{4-[2-Amino-6-(2,5-dichloro-phenyl)-pyrimidin-4-yl-amino]-phenyl}-methanol | 774606-26-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: {4-[2-Amino-6-(2,5-dichloro-phenyl)-pyrimidin-4-yl-amino]-phenyl}-methanol
• 英文别名: [4-[[2-Amino-6-(2,5-dichlorophenyl)pyrimidin-4-yl]amino]phenyl]methanol
• CAS: 774606-26-7
• 化学式: C₁₇H₁₄Cl₂N₄O
• 分子量: 361.23
• InChiKey: ZXGYEUGWKAWNQA-UHFFFAOYSA-N

物化性质

• 沸点：
  623.5±65.0 °C(Predicted)
• 密度：
  1.461±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  84.1
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Pyrimidines and uses thereof
  申请人：Cell Therapeutics, Inc.

  公开号：US20040204386A1

  公开（公告）日：2004-10-14

  The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase &bgr; (LPAAT-&bgr;) activity and/or proliferation of cells such as tumor-cells.

  这项发明涉及嘧啶类化合物及其用途，包括抑制溶磷脂酸酰基转移酶β（LPAAT-β）活性和/或抑制肿瘤细胞等细胞的增殖。
• PYRIMIDINES AND USES THEREOF
  申请人：BHATT Rama

  公开号：US20090099183A1

  公开（公告）日：2009-04-16

  The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor-cells.

  本发明涉及嘧啶及其用途，包括抑制溶血磷脂酸酰转移酶β（LPAAT-β）活性和/或细胞增殖，例如肿瘤细胞。
• Identification of genetic markers associated with parkinson disease
  申请人：Vance M. Jeffery

  公开号：US20060068428A1

  公开（公告）日：2006-03-30

  The present invention provides methods and compositions for screening a subject for Parkinson disease, for increased risk of developing Parkinson disease and/or for an earlier or later age of developing Parkinson disease, comprising detecting the presence of a genetic marker associated with Parkinson disease.
• IDENTIFICATION OF GENETIC MARKERS ASSOCIATED WITH PARKINSON DISEASE
  申请人：Vance Jeffery M.

  公开号：US20090098557A1

  公开（公告）日：2009-04-16

  The present invention provides methods and compositions for screening a subject for Parkinson disease, for increased risk of developing Parkinson disease and/or for an earlier or later age of developing Parkinson disease, comprising detecting the presence of a genetic marker associated with Parkinson disease.
• US7419984B2
  申请人：——

  公开号：US7419984B2

  公开（公告）日：2008-09-02