N-[4-(morpholin-4-yl)-6-oxo-2-phenyl-1,6-dihydropyrimidin-5-yl]benzamide | 1190744-65-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-(morpholin-4-yl)-6-oxo-2-phenyl-1,6-dihydropyrimidin-5-yl]benzamide
• 英文别名: N-(4-morpholin-4-yl-6-oxo-2-phenyl-1H-pyrimidin-5-yl)benzamide
• CAS: 1190744-65-0
• 化学式: C₂₁H₂₀N₄O₃
• 分子量: 376.415
• InChiKey: PXRCPYVUUHSDAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吗啉 、 4(5)-benzoylamino-4(5)-dichloromethyl-2-phenyl-4H(5H)-5(4)-imidazolone 反应 12.0h， 以47%的产率得到N-[4-(morpholin-4-yl)-6-oxo-2-phenyl-1,6-dihydropyrimidin-5-yl]benzamide
  参考文献：
  名称：

  Conversion of 2-aryl-4-dichloromethylen-5(4H)oxazolones to 5-acylamino-substituted pyrimidine bases

  摘要：

  Available polycentral unsaturated azlactones with 4-dichloromethylene group by successive treating with benzamidine and then with morpholine or its analogs were converted to substituted 5-acylamino-4-hydroxypyrimidines containing the residues of the corresponding nitrogen bases in the position 6. The structure of these cyclization products is consistent with the scheme of their preparation and has been confirmed also by H-1 NMR spectroscopy and XRD analysis.

  DOI：

  10.1134/s1070363209030256

文献信息

• Conversion of 2-aryl-4-dichloromethylen-5(4H)oxazolones to 5-acylamino-substituted pyrimidine bases
  作者：V. M. Prokopenko、V. N. Sviripa、S. G. Pil’o、V. S. Brovarets、A. N. Chernega、B. S. Drach

  DOI：10.1134/s1070363209030256

  日期：2009.3

  Available polycentral unsaturated azlactones with 4-dichloromethylene group by successive treating with benzamidine and then with morpholine or its analogs were converted to substituted 5-acylamino-4-hydroxypyrimidines containing the residues of the corresponding nitrogen bases in the position 6. The structure of these cyclization products is consistent with the scheme of their preparation and has been confirmed also by H-1 NMR spectroscopy and XRD analysis.