2,2-dimethyl-hexan-3-one-(2,4-dinitro-phenylhydrazone) | 111240-08-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-dimethyl-hexan-3-one-(2,4-dinitro-phenylhydrazone)
• 英文别名: 2,2-Dimethyl-hexan-3-on-(2,4-dinitro-phenylhydrazon)
• CAS: 111240-08-5
• 化学式: C₁₄H₂₀N₄O₄
• 分子量: 308.337
• InChiKey: CTINPKNCQXXQQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.12
• 重原子数：
  22.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  110.67
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  2,2-二甲基-3-己醇 在 铬酸 作用下， 生成 2,2-dimethyl-hexan-3-one-(2,4-dinitro-phenylhydrazone)
  参考文献：
  名称：

  Effects of Gap Junction Uncoupling in the Gerbil Cochlea

  摘要：

  AbstractObjective To gain insight into molecular and cellular mechanisms regulating cochlear potassium (K+) recycling, including the possible effects of mutations in the GJB2 gene, which encodes the gap junction protein connexin 26. Intercellular K+ flux was manipulated in vivo by infusion of the gap junction uncoupler proadifen (SKF‐525A) into perilymph. Functional and structural alterations induced by gap junction blockade were assessed by electrophysiological and morphologic analysis.Study Design Laboratory study using an animal model.Methods Physiological effects of acute and chronic uncoupling of gap junctions in the Mongolian gerbil inner ear were evaluated by measurement of compound action potential (CAP) thresholds and input‐output (I/O) functions, distortion product otoacoustic emissions (DPOAE), and the endocochlear potential (EP). Morphologic changes were assessed by electron microscopy.Results Acute exposures to proadifen resulted in large decreases in EP values, DPOAE magnitudes, and CAP I/O maximum amplitudes and an increase in high‐frequency CAP thresholds. These physiological changes were accompanied by vacuolization of type II and type V fibrocytes in the lateral wall of the cochlea. Chronic treatments revealed some recovery in EP values and CAP thresholds, which showed a relatively flat 15‐ to 20‐dB elevation across frequencies.Conclusions Gap junctions play a significant role in normal cochlear function. In particular they appear to be essential for maintaining the EP, an activity that could be related to their participation in K+ recycling. Thus, hearing losses associated with mutations in the GJB2 gene that alter the expression or function of connexin 26 may result from a diminished capacity to recycle K+ from perilymph back to the stria vascularis and a consequent decline in the EP.

  DOI：

  10.1097/00005537-200209000-00020

文献信息

• Whitmore et al., Journal of the American Chemical Society, 1941, vol. 63, p. 647
  作者：Whitmore et al.

  DOI：——

  日期：——
• Synthesis of Aliphatic <i>t</i>-Butyl Ketones
  作者：Frank C. Whitmore、Clarence I. Noll、Vincent C. Meunier

  DOI：10.1021/ja01872a043

  日期：1939.3