N-(2-aminoethyl)-2-(pyridin-4-yl)pyrido[3,4-d]pyrimidin-4-amine | 1352141-06-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(2-aminoethyl)-2-(pyridin-4-yl)pyrido[3,4-d]pyrimidin-4-amine
• 英文别名: N¹-(2-(pyridin-4-yl)pyrido[3,4-d]pyrimidin-4-yl)ethane-1,2-diamine；N'-(2-pyridin-4-ylpyrido[3,4-d]pyrimidin-4-yl)ethane-1,2-diamine
• CAS: 1352141-06-0
• 化学式: C₁₄H₁₄N₆
• 分子量: 266.305
• InChiKey: JHLONFVVTLRHIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Azaquinazoline Inhibitors of Atypical Protein Kinase C
  申请人：Cancer Research Technology Limited

  公开号：US20140113882A1

  公开（公告）日：2014-04-24

  The present application provides a compound of formula (I) or a salt thereof, wherein R 7 , R 8 , R 9 , G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

  本申请提供了式（I）的化合物或其盐，其中R7，R8，R9，G和X的定义如本文所述。本申请还描述了包含该化合物的组合物。式（I）的化合物及其盐具有aPKC抑制活性，并可用于治疗增生性疾病。
• [EN] AZAQUINAZOLINE INHIBITORS OF ATYPICAL PROTEIN KINASE C<br/>[FR] INHIBITEURS DE TYPE AZAQUINAZOLINE DE PROTÉINE KINASE C ATYPIQUE
  申请人：IGNYTA INC

  公开号：WO2014052699A9

  公开（公告）日：2015-07-16
• AZAQUINAZOLINE INHIBITORS OF ATYPICAL PROTEIN KINASE C
  申请人：CANCER RESEARCH TECHNOLOGY LIMITED

  公开号：EP2900666B1

  公开（公告）日：2020-11-04
• 6-6 Fused Bicyclic Heteroaryl Compounds and their Use as LATS Inhibitors
  申请人：Novartis AG

  公开号：US20180344738A1

  公开（公告）日：2018-12-06

  The present invention is related to 6-6 Fused Bicyclic Heteroaryl Compounds of the Formula A2 or A1 and their Use as LATS Inhibitors, or a salt, stereoisomer or pharmaceutical composition thereof; wherein the variables are as defined herein. The present invention further relates to a method of LATS inhibition in a cell population using a compound of Formula A1, or a salt, stereoisomer or pharmaceutical composition thereof. The present invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, their use in the treatment and management of diseases or disorders.
• US9896446B2
  申请人：——

  公开号：US9896446B2

  公开（公告）日：2018-02-20