6-bromo-7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone | 1261062-60-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 6-bromo-7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone
• 英文别名: 6-bromo-7-phenylsulfanyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one
• CAS: 1261062-60-5
• 化学式: C₁₄H₁₄BrNOS
• 分子量: 324.241
• InChiKey: BJHLORAMNUBFQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-bromo-7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone 、 苯硼酸 在 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 甲苯 为溶剂， 反应 48.0h， 以71%的产率得到6-phenyl-7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone
  参考文献：
  名称：

  Synthetic Applications of Sulfur-Substituted Indolizidines and Quinolizidines

  摘要：

  Starting from the sulfur-substituted indolizidines and quinolizidines, a few useful synthetic transformations have been developed and the synthesis of some natural products including indolizidine 209D, epimyrtine, lasubine II, 8a-epi-dendroprimine, and 5-epi-cermizine C has been accomplished.

  DOI：

  10.1021/jo102092b
• 作为产物：
  描述：

  6-(3-choloropropyl)-4-(phenylthio)-1,2,5,6-tetrahydro-2-pyridinone 在 N-溴代丁二酰亚胺(NBS) 、 sodium hydride 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 5.0h， 生成 6-bromo-7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone
  参考文献：
  名称：

  Synthetic Applications of Sulfur-Substituted Indolizidines and Quinolizidines

  摘要：

  Starting from the sulfur-substituted indolizidines and quinolizidines, a few useful synthetic transformations have been developed and the synthesis of some natural products including indolizidine 209D, epimyrtine, lasubine II, 8a-epi-dendroprimine, and 5-epi-cermizine C has been accomplished.

  DOI：

  10.1021/jo102092b

文献信息

• Synthetic Applications of Sulfur-Substituted Indolizidines and Quinolizidines
  作者：Shang-Shing P. Chou、Yi-Ching Chung、Po-An Chen、Shan-Lun Chiang、Chien-Jung Wu

  DOI：10.1021/jo102092b

  日期：2011.1.21

  Starting from the sulfur-substituted indolizidines and quinolizidines, a few useful synthetic transformations have been developed and the synthesis of some natural products including indolizidine 209D, epimyrtine, lasubine II, 8a-epi-dendroprimine, and 5-epi-cermizine C has been accomplished.