(R)-N-Methyl-1-phenylpropylamine | 128257-18-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-N-Methyl-1-phenylpropylamine
• 英文别名: (αR)-α-ethyl-N-methylbenzenemethanamine；Methyl-((R)-1-phenyl-propyl)-amine；(1R)-N-methyl-1-phenylpropan-1-amine
• CAS: 128257-18-1
• 化学式: C₁₀H₁₅N
• 分子量: 149.236
• InChiKey: YELGXBUYFOSFJM-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (R)-N-Methyl-1-phenylpropylamine 在 4-二甲氨基吡啶 盐酸 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 1,4-二氧六环 、 乙醚 、 二氯甲烷 、 乙腈 为溶剂， 反应 100.0h， 生成 N-methyl-2-[1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-N-[(1R)-1-phenylpropyl]-4-thiazolecarboxamide
  参考文献：
  名称：

  [EN] FUNGICIDAL CARBOXAMIDES
  [FR] CARBOXAMIDES FONGICIDES

  摘要：

  公开号：

  WO2007014290A3
• 作为产物：
  描述：

  乙基溴化镁 、 (2R,4S,5R)-3,4-dimethyl-2,5-diphenyloxazolidine 生成 (R)-N-Methyl-1-phenylpropylamine
  参考文献：
  名称：

  Asymmetric synthesis. II. Synthesis and absolute configuration of oxazolidines derived from (-)-ephedrine and aromatic aldehydes

  摘要：

  DOI：

  10.1021/jo00815a012

文献信息

• Beta lactam compounds and their use as inhibitors of tryptase
  申请人：Bristol-Myers Squibb Co.

  公开号：US06335324B1

  公开（公告）日：2002-01-01

  Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.

  这些化合物的结构式已被披露。这些化合物抑制色胺酸蛋白酶以及其他酶系统，或者是选择性色胺酸蛋白酶抑制剂，并且在特别是治疗慢性哮喘方面作为抗炎药物是有用的。
• Highly diastereoselective reaction of (3aS,6R)-5-oxa-7,8a-diazaperhydroazulen-8-ones with diethylzinc.
  作者：Hiroshi TAKAHASHI、Ichiro MORIMOTO、Kimio HIGASHIYAMA

  DOI：10.1248/cpb.38.2627

  日期：——

  New chiral heterocyclic compounds, (3aS, 6R)-5-oxa-7, 8a-diazaperhydroazulen-8-ones (2a-c), were synthesized and their absolute configurations were determined by X-ray analysis. The reaction of (3aS, 6R)-2a-c with diethylzinc proceeded under mild conditions with extremely high diastereoselectivity.

  新型手性杂环化合物（3aS, 6R）-5-氧-7, 8a-二氮杂环辛烷-8-酮（2a-c）被合成，并通过X射线分析确定了它们的绝对构型。与二乙基锌的反应在温和条件下进行，具有极高的二对映体选择性。
• COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Heine Niklas

  公开号：US20100168070A1

  公开（公告）日：2010-07-01

  The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R 1 -R 13 , A, B, L and i are as defined in the description and in the claims. The invention also relates to the use thereof for treating Alzheimer's disease (AD) and similar diseases.

  该发明涉及一般式(I)的取代1,2-乙二胺，其中基团R1-R13、A、B、L和i如描述和索赔中所定义。该发明还涉及将其用于治疗阿尔茨海默病（AD）和类似疾病。
• Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors
  申请人：Allen George David

  公开号：US20070111995A1

  公开（公告）日：2007-05-17

  The invention provides pyrazolo[3,4-b]pyridine compounds of formula (I) having a —C(O)—NH—C(R 4 )(R 5 )-aryl substituent at the 5-position of the pyrazolo[3,4-b]pyridine ring system wherein at least one of R 4 and R 5 is not a hydrogen atom (H) compound or a salt thereof: wherein Ar has the sub-formula (x) or (z). These compounds are useful as inhibitors of PDE4.

  本发明提供了式(I)的吡唑并[3,4-b]吡啶化合物，其在吡唑并[3,4-b]吡啶环系的5位具有—C(O)—NH—C(R4)(R5)-芳基取代基，其中R4和R5中至少有一个不是氢原子（H）化合物或其盐：其中Ar具有亚式（x）或（z）。这些化合物可用作PDE4的抑制剂。
• Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors
  申请人：Coe Mary Diane

  公开号：US20070167485A1

  公开（公告）日：2007-07-19

  The invention relates to a compound of formula (I) or a salt thereof: wherein: R 1 is Et, n-Pr, i-Pr, C 2 fluoroalkyl, or —CH 2 CH 2 OH; R 2 is H, Me, Et, n-Pr, i-Pr, C 1-2 fluoroalkyl, cyclopropyl or (cyclopropyl)methyl-; and NHR 3 has the sub-formula (nhr3): wherein R 3a is methyl or ethyl; R 3b is H, methyl or ethyl; R 3c is H, methyl or ethyl, R 3d is H, methyl or ethyl, and R 3e is H or methyl, provided that: (a) R 3b is methyl or ethyl; and/or (b) R 3c and R 3d are independently methyl or ethyl; and provided that: (c) when R 3c is ethyl and/or when R 3d is ethyl and/or when R 3e is methyl, then: R 3a is methyl and/or R 3b is hydrogen or methyl. These compounds are PDE4 inhibitors.

  本发明涉及式（I）的化合物或其盐：其中：R1为Et，n-Pr，i-Pr，C2氟烷基或—CH2CH2OH；R2为H，Me，Et，n-Pr，i-Pr，C1-2氟烷基，环丙基或（环丙基）甲基-；以及NHR3具有亚式（nhr3）：其中R3a为甲基或乙基；R3b为H，甲基或乙基；R3c为H，甲基或乙基；R3d为H，甲基或乙基，且R3e为H或甲基，前提是：（a）R3b为甲基或乙基；和/或（b）R3c和R3d独立地为甲基或乙基；并且前提是：（c）当R3c为乙基和/或当R3d为乙基和/或当R3e为甲基时，则：R3a为甲基和/或R3b为氢或甲基。这些化合物是PDE4抑制剂。