2-Amino-5-bromo-N-cyclopropylbenzamide | 1263377-69-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Amino-5-bromo-N-cyclopropylbenzamide
• CAS: 1263377-69-0
• 化学式: C₁₀H₁₁BrN₂O
• 分子量: 255.114
• InChiKey: HJGALSGTDWHWKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Amino-5-bromo-N-cyclopropylbenzamide 、 methyl (E)-4-(2-formylphenoxy)but-2-enoate 在 Amberlite 15 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 生成 methyl (Z)-4-[2-(6-bromo-3-cyclopropyl-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)phenoxy]but-2-enoate
  参考文献：
  名称：

  Simple and Efficient Amberlite 15-catalyzed Synthesis of Dihydroquinazolinones

  摘要：

  The Amberlite 15 catalyzed synthesis of substituted 2,3-dihydroquinazolin-4(1H)-ones was reported. The reaction conditions were optimized by screening in different solvents and catalysts. The substrate scope of the reaction was also studied, and a plausible mechanism for the reaction was proposed.

  DOI：

  10.1134/s1070428020080199
• 作为产物：
  描述：

  5-溴靛红酸酐 、 环丙胺 以 1,4-二氧六环 为溶剂， 反应 1.0h， 生成 2-Amino-5-bromo-N-cyclopropylbenzamide
  参考文献：
  名称：

  Simple and Efficient Amberlite 15-catalyzed Synthesis of Dihydroquinazolinones

  摘要：

  The Amberlite 15 catalyzed synthesis of substituted 2,3-dihydroquinazolin-4(1H)-ones was reported. The reaction conditions were optimized by screening in different solvents and catalysts. The substrate scope of the reaction was also studied, and a plausible mechanism for the reaction was proposed.

  DOI：

  10.1134/s1070428020080199