(R)-5-(氨基甲基)吡咯烷-2-酮盐酸盐 | 1956434-90-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: (R)-5-(氨基甲基)吡咯烷-2-酮盐酸盐
• 英文名称: (R)-5-aminomethylpyrrolidin-2-one hydrochloride
• 英文别名: (R)-5-(Aminomethyl)pyrrolidin-2-one hydrochloride；(5R)-5-(aminomethyl)pyrrolidin-2-one;hydrochloride
• CAS: 1956434-90-4
• 化学式: C₅H₁₀N₂O*ClH
• 分子量: 150.608
• InChiKey: UJBDBOYWHDPFLK-PGMHMLKASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.35
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.1
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  3-fluoro-5-methoxy-2',2''-dimethyl-3''-(pyrido[3,4-b]pyrazin-5-ylamino)-[1,1':3',1''-terphenyl]-4-carbaldehyde 、 (R)-5-(氨基甲基)吡咯烷-2-酮盐酸盐 、 三氟乙酸 在 溶剂黄146 、 三乙胺 、 乙醇 、 三乙酰氧基硼氢化钠 作用下， 以 乙醇 、 水 、 乙腈 为溶剂， 反应 0.83h， 生成 (R)-5-((((3-fluoro-5-methoxy-2',2''-dimethyl-3''-(pyrido[3,4-b]pyrazin-5-ylamino)-[1,1':3',1''-terphenyl]-4-yl)methyl)amino)methyl)pyrrolidin-2-one trifluoroacetate
  参考文献：
  名称：

  [EN] TRIARYL COMPOUNDS FOR TREATMENT OF PD-L1 DISEASES
  [FR] COMPOSÉS TRIARYLES POUR LE TRAITEMENT DE MALADIES PD-L1

  摘要：

  提供了一些作为免疫调节剂有用的化合物。这些化合物具有公式（I），包括立体异构体和其药用盐，其中R1a、R1b、R1c、R1d、R2a、R2b、R3、R3a、R4、R6、R7、R8、A、Z、X1和n如本文所定义。还披露了与这些化合物的制备和使用相关的方法，以及包含这些化合物的药物组合物。

  公开号：

  WO2020232256A1

文献信息

• [EN] HETEROARYL-BIPHENYL AMINES FOR THE TREATMENT OF PD-L1 DISEASES<br/>[FR] HÉTÉROARYL-BIPHÉNYLAMINES POUR LE TRAITEMENT DE MALADIES PD-L1
  申请人：CHEMOCENTRYX INC

  公开号：WO2021076688A1

  公开（公告）日：2021-04-22

  Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  提供了作为免疫调节剂有用的化合物。这些化合物具有公式（I），包括立体异构体和其药用盐，其中R2a、R2b、R3、R3a、R4、R6、R7、R8、A、Z、X1和n的定义如本文所述。还公开了与制备和使用这些化合物相关的方法，以及包含这些化合物的药物组合物。
• Triaryl compounds for treatment of PD-L1 diseases
  申请人：CHEMOCENTRYX, INC.

  公开号：US11266643B2

  公开（公告）日：2022-03-08

  Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本研究提供了可用作免疫调节剂的化合物。这些化合物具有式（I） 其中 R1a、R1b、R1c、R1d、R2a、R2b、R3、R3a、R4、R6、R7、R8、A、Z、X1 和 n 如本文所定义。还公开了与制备和使用此类化合物相关的方法，以及包含此类化合物的药物组合物。
• HETEROARYL-BIPHENYL AMINES FOR THE TREATMENT OF PD-L1 DISEASES
  申请人：ChemoCentryx, Inc.

  公开号：EP4045037A1

  公开（公告）日：2022-08-24
• TRIARYL COMPOUNDS FOR TREATMENT OF PD-L1 DISEASES
  申请人：CHEMOCENTRYX, INC.

  公开号：US20200383979A1

  公开（公告）日：2020-12-10

  Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1a , R 1b , R 1c , R 1d , R 2a , R 2b , R 3 , R 3a , R 4 , R 6 , R 7 , R 8 , A, Z, X 1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
• HETEROARYL-BIPHENYL AMIDES FOR THE TREATMENT OF PD-L1 DISEASES
  申请人：CHEMOCENTRYX, INC.

  公开号：US20210130325A1

  公开（公告）日：2021-05-06

  Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 2a , R 2b , R 3 , R 3a , R 4 , R 6 , R 7 , R 8 , A, Z, X 1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.