3-Aethoxy-1-phenyl-propanol-(1) | 18776-18-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Aethoxy-1-phenyl-propanol-(1)
• 英文别名: 3-Ethoxy-1-phenylpropan-1-ol
• CAS: 18776-18-6
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: FCNLXBFQNHVTIR-UHFFFAOYSA-N

物化性质

• 沸点：
  147 °C(Press: 15 Torr)
• 密度：
  1.021±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Aethoxy-1-phenyl-propanol-(1) 在 铬酸 作用下， 生成 3-ethoxy-1-phenyl-1-propanone
  参考文献：
  名称：

  Synthesis and muscarinic cholinergic receptor affinities of 3-quinuclidinyl .alpha.-(alkoxyalkyl)-.alpha.-aryl-.alpha.-hydroxyacetates

  摘要：

  Seven analogues of 3-quinuclidinyl benzilate (QNB) in which one phenyl ring was replaced by an alkoxyalkyl moiety were synthesized and their affinities for the muscarinic cholinergic receptor determined. An oxygen in the beta-position of the moiety was not well-tolerated. By contrast, an oxygen in the gamma-position did not change the affinity for the muscarinic receptor. However, when a bromine was placed on the remaining phenyl ring, the affinity was significantly reduced in striking contrast to results obtained on halogenation of QNB.

  DOI：

  10.1021/jm00114a006
• 作为产物：
  描述：

  苯乙烯 在 氢氧化钾 、 zinc(II) chloride 作用下， 以 四氯化碳 为溶剂， 生成 3-Aethoxy-1-phenyl-propanol-(1)
  参考文献：
  名称：

  Synthesis and muscarinic cholinergic receptor affinities of 3-quinuclidinyl .alpha.-(alkoxyalkyl)-.alpha.-aryl-.alpha.-hydroxyacetates

  摘要：

  Seven analogues of 3-quinuclidinyl benzilate (QNB) in which one phenyl ring was replaced by an alkoxyalkyl moiety were synthesized and their affinities for the muscarinic cholinergic receptor determined. An oxygen in the beta-position of the moiety was not well-tolerated. By contrast, an oxygen in the gamma-position did not change the affinity for the muscarinic receptor. However, when a bromine was placed on the remaining phenyl ring, the affinity was significantly reduced in striking contrast to results obtained on halogenation of QNB.

  DOI：

  10.1021/jm00114a006

文献信息

• A Formal anti-Markovnikov Hydroalkoxylation of Allylic Alcohols with a Ruthenium Catalyst
  作者：Yushi Nakamura、Tetsuo Ohta、Yohei Oe

  DOI：10.1246/cl.171104

  日期：2018.3.5

  Hydroalkoxylation of C–C double bonds was achieved through the use of a ruthenium catalyst. The reaction of allylic alcohols with nucleophilic alcohols was carried out in the presence of a ruthenium catalyst prepared by RuClH(CO)(PPh3)3 and 2,6-bis(n-butyliminomethyl)-4-(piperidin-1-yl)pyridine under mild reaction conditions to afford the corresponding γ-alkoxypropanols in good yield.

  C-C双键的氢烷氧基化是通过使用钌催化剂实现的。烯丙醇与亲核醇的反应是在 RuClH(CO)(PPh3)3 和 2,6-双(正丁基亚氨基甲基)-4-(哌啶-1-基)吡啶制备的钌催化剂存在下进行的在温和的反应条件下，以良好的收率得到相应的γ-烷氧基丙醇。
• 614. Quinolizines. Part II. A synthesis of alkyl- and of aryl-quinolizinium salts
  作者：E. E. Glover、Gurnos Jones

  DOI：10.1039/jr9580003021

  日期：——
• Enantioselective chiral borane-mediated aldol reactions of silyl ketene acetals with aldehydes. The novel effect of the trialkysilyl group of the silyl ketene acetal on the reaction course
  作者：Syunichi Kiyooka、Yuichi Kaneko、Misako Komura、Hidehito Matsuo、Masahito Nakano

  DOI：10.1021/jo00007a003

  日期：1991.3

  Highly enantioselective aldol reactions of silyl ketene acetals with a variety of aldehydes were achieved by using chiral boranes prepared from the sulfonamides of alpha-amino acids.
• CYCLOPROPANE HYDROCARBONS FROM gamma-BROMOETHERS¹
  作者：J. T. GRAGSON、K. W. GREENLEE、J. M. DERFER、C. E. BOORD

  DOI：10.1021/jo01121a001

  日期：1955.3
• Synthesis of 3-hydroxy aldehydes, 3-hydroxy acetals, and 3-hydroxy ethers from 2-alkoxy oxetanes
  作者：Siegfried H. Schroeter

  DOI：10.1021/jo01257a002

  日期：1969.5