2-Chloro-4-[4-(dimethylamino)phenyl]aniline | 1417453-35-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Chloro-4-[4-(dimethylamino)phenyl]aniline
• 英文别名: 2-chloro-4-[4-(dimethylamino)phenyl]aniline
• CAS: 1417453-35-0
• 化学式: C₁₄H₁₅ClN₂
• 分子量: 246.739
• InChiKey: NDDZKQXKUUGZGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二苯甲酮 、 2-Chloro-4-[4-(dimethylamino)phenyl]aniline 在 zinc(II) chloride 作用下， 以 甲苯 为溶剂， 生成 4-[4-(benzhydrylideneamino)-3-chlorophenyl]-N,N-dimethylaniline
  参考文献：
  名称：

  Intramolecular Direct C–H Bond Arylation from Aryl Chlorides: A Transition-Metal-Free Approach for Facile Access of Phenanthridines

  摘要：

  A C-H arylation with aryl chloride Is made viable through a transition-metal-free approach. In the presence of a simple diol associating with KOt-Bu, various phenanthridine derivatives can be conveniently accessed. In particular, only 10 mol % of simple and inexpensive ethylene glycol is required for this protocol. These results represent the first general examples of aryl chloride/C-H coupling under transition-metal-free conditions.

  DOI：

  10.1021/ol302489n

文献信息

• Intramolecular Direct C–H Bond Arylation from Aryl Chlorides: A Transition-Metal-Free Approach for Facile Access of Phenanthridines
  作者：Yinuo Wu、Shun Man Wong、Fei Mao、Tek Long Chan、Fuk Yee Kwong

  DOI：10.1021/ol302489n

  日期：2012.10.19

  A C-H arylation with aryl chloride Is made viable through a transition-metal-free approach. In the presence of a simple diol associating with KOt-Bu, various phenanthridine derivatives can be conveniently accessed. In particular, only 10 mol % of simple and inexpensive ethylene glycol is required for this protocol. These results represent the first general examples of aryl chloride/C-H coupling under transition-metal-free conditions.