PtMe(iC₃F₇)(COD) | 887305-17-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: PtMe(iC₃F₇)(COD)
• 英文别名: carbanide;(1Z,5Z)-cycloocta-1,5-diene;1,1,1,2,3,3,3-heptafluoropropane;platinum(2+)
• CAS: 887305-17-1
• 化学式: C₁₂H₁₅F₇Pt
• 分子量: 487.32
• InChiKey: JEZHLUAJSNJEMJ-PHFPKPIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  (1,5-cyclooctadiene)dimethylplatinum(II) 、 七氟-2-碘代丙烷 以 further solvent(s) 为溶剂， 以85%的产率得到PtMe(iC₃F₇)(COD)
  参考文献：
  名称：

  正和异全氟丙基碘化物和正全氟丁基碘化物在室温下取代二甲基铂 (II) 1,5-环辛二烯：[Pt(C3F7)2(COD)] 的晶体结构

  摘要：

  摘要 二甲基铂 (II)COD [COD = 1,5-环辛二烯] 与摩尔过量的全氟正丙基碘在室温下反应生成 [Pt(C 3 F 7 ) 2 (COD)]。全氟异丙基碘和全氟正丁基碘生成单取代基 [Pt( i -C 3 F 7 )(CH 3 )(COD)] 和 [Pt(C 4 F 9 )(CH 3 )(COD) ]，分别与抑制第二次取代反应的空间位阻一致。[Pt(C 3 F 7 ) 2 (COD)] 的晶体结构揭示了铂的方形平面几何形状。

  DOI：

  10.1016/j.inoche.2005.05.022

文献信息

• Cytotoxicity and NMR Studies of Platinum Complexes with Cyclooctadiene Ligands
  作者：Mirja Enders、Benjamin Görling、Alexander B. Braun、Judith E. Seltenreich、Linus F. Reichenbach、Kari Rissanen、Martin Nieger、Burkhard Luy、Ute Schepers、Stefan Bräse

  DOI：10.1021/om500540x

  日期：2014.8.11

  The synthesis of a series of platinum complexes containing cyclooctadiene ligands with the general structure PtMeL(R-cod) (where L = Cl, I, nC3F7, iC3F7, nC8F17, Me, aryl, alkynyl and R = H, Me, Et, iPr, nBu, iBu, nHex, Ph) is presented. All complexes are remarkably stable and were obtained in excellent yields. Their structure in both solution and the solid state were explored by crystal structures

  合成一系列具有一般结构PtMeL（R-cod）的环辛二烯配体的铂配合物（其中L = Cl，I，n C 3 F 7，i C 3 F 7，n C 8 F 17，Me，芳基，炔基，R = H，Me，Et，i Pr，n Bu，i Bu，n Hex，Ph）。所有复合物都非常稳定，并以极高的收率获得。通过晶体结构和多核（1 H，13 C，19F，195Pt）NMR光谱。在大多数细胞结构中，与顺铂相比，在HeLa细胞中选择的复合物的细胞毒性实验显示出更高的毒性。
• Influence of Perfluorinated End Groups on the SFRD of [Pt(cod)Me(C_<i>n</i>F_2<i>n</i>+1)] onto Porous Al₂O₃in CO₂under Reductive Conditions
  作者：Vikas Aggarwal、Linus F. Reichenbach、Mirja Enders、Thierry Muller、Simone Wolff、Marlene Crone、Michael Türk、Stefan Bräse

  DOI：10.1002/chem.201301191

  日期：2013.9.16

  2 nm. Furthermore, substitution of the CH3 end group by the CnF2n+1 end groups led to a significant drop in Pt loading of about 50 %. Within the series of perfluorinated end groups that were considered, the Pt complex that contained a branched perfluoro‐isopropyl group showed the most‐interesting results when compared to the control precursor, [Pt(cod)Me2] (1).

  提出了一系列包含不同全氟烷烃链[Pt（cod）Me（C n F 2 n +1）]的环辛二烯稳定的Pt配合物的优化合成。这些金属有机化合物被用于还原条件下在CO 2中所谓的超临界流体反应沉积（SFRD），以在氧化铝上作为多孔载体生成金属纳米颗粒。因此，获得了具有窄粒度分布的Al 2 O 3负载的Pt纳米颗粒。在15.5 MPa的减压压力和353 K的温度下，d 50的粒径产生了= 2.3–2.8 nm。在还原反应过程中降低压力会导致颗粒稍大，同时减少CO 2中有机金属前体的量会使粒径从x 50 = 3.2 nm减小到2.6 nm，粒径分布为2.2 nm。此外，CH 3端基被C n F 2 n +1端基取代导致Pt载量显着下降约50％。在考虑的一系列全氟端基中，与支链前体[Pt（cod）Me 2 ]相比，包含支链全氟异丙基的Pt络合物显示出最有趣的结果。1）。
• Platinum Cyclooctadiene Complexes with Activity against Gram‐positive Bacteria
  作者：Angelo Frei、Soumya Ramu、Gabrielle J. Lowe、Hue Dinh、Lucie Semenec、Alysha G. Elliott、Johannes Zuegg、Anke Deckers、Nicole Jung、Stefan Bräse、Amy K. Cain、Mark A. T. Blaskovich

  DOI：10.1002/cmdc.202100157

  日期：2021.10.15

  Metalloantibiotics: Platinum complexes are mostly known for their anticancer properties, most famously in the drug cisplatin. Herein we describe the high antibacterial properties of platinum cyclooctadiene (COD) complexes. Some of these complexes display MIC values in the nanomolar range while manifesting no toxicity in vitro and in vivo.

  金属抗生素：铂络合物以其抗癌特性而闻名，最著名的是药物顺铂。在此，我们描述了铂环辛二烯 (COD) 配合物的高抗菌特性。其中一些复合物的 MIC 值在纳摩尔范围内，同时在体外和体内表现出无毒性。
• Fluoroalkylation of a Methylplatinum(II) Complex under Photoirradiation
  作者：Yuji Suzaki、Minetada Kiho、Kohtaro Osakada

  DOI：10.1021/acs.organomet.7b00098

  日期：2017.4.10

  The UV irradiation of a mixture of PtMe2(cod) (cod = 1,5-cyclooctadiene) and n-C4F9I in a 1:12 molar ratio for 15 min produces Pt(n-C4F9)(2)(cod) in 61% yield at room temperature. The reaction without irradiation, as reported previously, proceeds much more slowly; heating the mixture for 7 days at 50 degrees C forms PtMe(n-C4F9)(cod) in 9% yield and no Pt(n-C4F9)(2)(cod). Pt(n-C4F9)(2)(cod) is converted to complexes having chelating ligands, Pt(n-C4F9)(2)(L) (L = dppe (1,2-bis(diphenylphosphino)ethane), dppp (1,3-bis(diphenylphosphino)propane), bpy (2,2'-bipyridine)). The photoassisted fluoroalkylation of PtMe(n-C4F9)(cod) also affords Pt(n-C4F9)(2)(cod), while the monomethylplatinum complexes PtMe(C6H4-4-F)(cod) and PtClMe(cod) react with n-C4F9I under photoirradiation to afford complexes with a perfluorobutyl ligand, Pt(n-C4F9)(C6H4-4-F)(cod) and PtCl(n-C4F9)(cod), respectively. The above reactions do not provide isolable Pt(IV) complexes, in contrast to the reactions of alkyl or fluoroalkyl iodides with diorganoplatinum(II) complexes having dinitrogen ligands. The mechanism of the fluoroalkylation of Pt(II) complexes under photoirradiation is discussed on the basis of the reaction products.