埃索美拉唑杂质1 | 1384163-92-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 埃索美拉唑杂质1
• 英文名称: Desulfoxide 4-demethyl omeprazole
• 英文别名: 2-[(6-methoxy-1H-benzimidazol-2-yl)methyl]-3,5-dimethyl-1H-pyridin-4-one
• CAS: 1384163-92-1
• 化学式: C₁₆H₁₇N₃O₂
• 分子量: 283.32
• InChiKey: JGZCGSDRNJLWDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  67
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Acid labile drug formulations
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP2345408A2

  公开（公告）日：2011-07-20

  Pharmaceutical formulations comprise inert cores that are coated with a composition comprising an acid labile drug, further sequentially coated with a barrier or intermediate layer and an enteric coating layer. Coated cores may be further formulated to produce tablets or capsules.

  药物制剂包括惰性芯材，芯材上涂有包含酸性药物的组合物，并依次涂有阻隔层或中间层以及肠溶包衣层。包衣芯可进一步配制成片剂或胶囊。
• PHARMACEUTICAL FORMULATIONS COMPRISING NSAID AND PROTON PUMP INHIBITOR DRUGS
  申请人：Movva Snehalatha

  公开号：US20110293713A1

  公开（公告）日：2011-12-01

  Aspects of the present application relate to pharmaceutical formulations comprising a nonsteroidal anti-inflammatory drug, together with a proton pump inhibitor drug, to reduce the incidence of gastrointestinal complications associated with chronic therapy with a nonsteroidal anti-inflammatory drug. Specific aspects of the application relate to fixed dose combinations comprising aspirin, or a derivative thereof, and omeprazole or esomeprazole, or pharmaceutically acceptable salts, solvates, or hydrates thereof.