1-(2-Methoxyethyl)-5-nitro-2-(3-phenylphenyl)benzimidazole | 1243576-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(2-Methoxyethyl)-5-nitro-2-(3-phenylphenyl)benzimidazole
• 英文别名: 1-(2-methoxyethyl)-5-nitro-2-(3-phenylphenyl)benzimidazole
• CAS: 1243576-37-5
• 化学式: C₂₂H₁₉N₃O₃
• 分子量: 373.411
• InChiKey: DCAUEIFHLTXEEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-苯基苯甲醛 、 2-氟-5-硝基苯胺 、 2-甲氧基乙胺 反应 8.0h， 以82%的产率得到1-(2-Methoxyethyl)-5-nitro-2-(3-phenylphenyl)benzimidazole
  参考文献：
  名称：

  A one-pot three-component reaction to access 1-alkyl-2-aryl-5-nitrobenzimidazoles under solvent-free conditions

  摘要：

  A novel and expeditious method to access 1-alkyl-2-aryl-5-nitiobenzimidazoles has been developed Enlisting solvent-free conditions, 2-fluoro-5-nitroaniline, a primary amine, and substituted aldehyde were melted together in one-pot to generate a variety of 1-alkyl-2-aryl-5-nitrobenzimidazoles (C) 2010 Elsevier Ltd All lights reserved

  DOI：

  10.1016/j.tetlet.2010.06.094

文献信息

• A one-pot three-component reaction to access 1-alkyl-2-aryl-5-nitrobenzimidazoles under solvent-free conditions
  作者：F. Anthony Romero、Remond Moningka

  DOI：10.1016/j.tetlet.2010.06.094

  日期：2010.8

  A novel and expeditious method to access 1-alkyl-2-aryl-5-nitiobenzimidazoles has been developed Enlisting solvent-free conditions, 2-fluoro-5-nitroaniline, a primary amine, and substituted aldehyde were melted together in one-pot to generate a variety of 1-alkyl-2-aryl-5-nitrobenzimidazoles (C) 2010 Elsevier Ltd All lights reserved