4-Chlor-1.3-dimethyl-5-isopropyl-uracil | 98959-07-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Chlor-1.3-dimethyl-5-isopropyl-uracil
• 英文别名: 6-chloro-5-isopropyl-1,3-dimethyl-1H-pyrimidine-2,4-dione；6-Chloro-1,3-dimethyl-5-propan-2-ylpyrimidine-2,4-dione
• CAS: 98959-07-0
• 化学式: C₉H₁₃ClN₂O₂
• 分子量: 216.667
• InChiKey: TZPMICSSVMBVPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• CHITOSAN COVALENTLY LINKED WITH SMALL MOLECULE INTEGRIN ANTAGONIST FOR TARGETED DELIVERY
  申请人：Hoffmann-La Roche Inc.

  公开号：US20180099005A1

  公开（公告）日：2018-04-12

  The invention relates to the chitosan polymer derivatives of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Y, X 1 , X 4 , R 1 , R 2 , and n are defined in the detailed description and claims. The chitosan polymer derivatives of formula I bind to or associate with alpha-4-beta-1 (α4β1) and alpha-V-beta-3 (α Vβ3) integrin dimers and can be used in delivery formulations to deliver drugs, nucleic acids, or other therapeutic compounds to tissues or cells expressing such integrins.