N-[[4-(2-azidoethoxy)phenyl]methyl]-1-[4-[4-[[[4-(2-azidoethoxy)phenyl]methylamino]methyl]phenyl]phenyl]methanamine | 1583273-70-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[[4-(2-azidoethoxy)phenyl]methyl]-1-[4-[4-[[[4-(2-azidoethoxy)phenyl]methylamino]methyl]phenyl]phenyl]methanamine
• CAS: 1583273-70-4
• 化学式: C₃₂H₃₄N₈O₂
• 分子量: 562.674
• InChiKey: NOGDZVKALFUTMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  42
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  71.2
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  ammonium hexafluorophosphate 、 N-[[4-(2-azidoethoxy)phenyl]methyl]-1-[4-[4-[[[4-(2-azidoethoxy)phenyl]methylamino]methyl]phenyl]phenyl]methanamine 在 盐酸 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 2.0h， 以97%的产率得到
  参考文献：
  名称：

  A Novel Pentiptycene Bis(crown ether)-Based [2](2)Rotaxane Whose Two DB24C8 Rings Act as Flapping Wings of a Butterfly

  摘要：

  A novel [2](2)rotaxane based on pentiptycene-derived bis(crown ether) can be efficiently synthesized via a "click chemistry" method and the subsequent N-methylation. Due to the different affinities of DB24C8 with the ammonium and triazolium stations, the wing-flapping movement of the DB24C8 "wings" in the [2](2)rotaxane can be easily achieved by acid/base stimulus.

  DOI：

  10.1021/ol500149k
• 作为产物：
  描述：

  BENZALDEHYDE-一聚乙二醇-叠氮 、 4,4'-二氨甲基联苯 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以75%的产率得到N-[[4-(2-azidoethoxy)phenyl]methyl]-1-[4-[4-[[[4-(2-azidoethoxy)phenyl]methylamino]methyl]phenyl]phenyl]methanamine
  参考文献：
  名称：

  A Novel Pentiptycene Bis(crown ether)-Based [2](2)Rotaxane Whose Two DB24C8 Rings Act as Flapping Wings of a Butterfly

  摘要：

  A novel [2](2)rotaxane based on pentiptycene-derived bis(crown ether) can be efficiently synthesized via a "click chemistry" method and the subsequent N-methylation. Due to the different affinities of DB24C8 with the ammonium and triazolium stations, the wing-flapping movement of the DB24C8 "wings" in the [2](2)rotaxane can be easily achieved by acid/base stimulus.

  DOI：

  10.1021/ol500149k

文献信息

• A Novel Pentiptycene Bis(crown ether)-Based [2](2)Rotaxane Whose Two DB24C8 Rings Act as Flapping Wings of a Butterfly
  作者：Ying-Xian Ma、Zheng Meng、Chuan-Feng Chen

  DOI：10.1021/ol500149k

  日期：2014.4.4

  A novel [2](2)rotaxane based on pentiptycene-derived bis(crown ether) can be efficiently synthesized via a "click chemistry" method and the subsequent N-methylation. Due to the different affinities of DB24C8 with the ammonium and triazolium stations, the wing-flapping movement of the DB24C8 "wings" in the [2](2)rotaxane can be easily achieved by acid/base stimulus.