1-(4-Methylphenyl)sulfonyl-4-prop-1-en-2-yltriazole | 1598463-35-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-Methylphenyl)sulfonyl-4-prop-1-en-2-yltriazole
• 英文别名: 1-(4-methylphenyl)sulfonyl-4-prop-1-en-2-yltriazole
• CAS: 1598463-35-4
• 化学式: C₁₂H₁₃N₃O₂S
• 分子量: 263.32
• InChiKey: SMLDRAYVLBNFLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  73.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-Methylphenyl)sulfonyl-4-prop-1-en-2-yltriazole 、 N,N-二乙基苯胺 在 dirhodium tetraacetate 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以55%的产率得到N-(2-(4-(diethylamino)phenyl)-3-methylbut-2-en-1-ylidene)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Rhodium Catalyzed Direct Arylation of α-Diazoimines

  摘要：

  An efficient rhodium catalyzed direct arylation of alpha-diazoimines, generated from readily accessible 1,2,3-triazole, has been accomplished for the synthesis of 2,2-diaryl enamides. The reaction involves the chemo- and regioselective insertion of rhodium azavinyl carbene into aromatic C(sp(2))-H bonds. Utility of the developed methodology was demonstrated in the synthesis of indole and tetrahydroisoquinoline frameworks.

  DOI：

  10.1021/ol500874p

文献信息

• Rhodium Catalyzed Direct Arylation of α-Diazoimines
  作者：Dongari Yadagiri、Pazhamalai Anbarasan

  DOI：10.1021/ol500874p

  日期：2014.5.2

  An efficient rhodium catalyzed direct arylation of alpha-diazoimines, generated from readily accessible 1,2,3-triazole, has been accomplished for the synthesis of 2,2-diaryl enamides. The reaction involves the chemo- and regioselective insertion of rhodium azavinyl carbene into aromatic C(sp(2))-H bonds. Utility of the developed methodology was demonstrated in the synthesis of indole and tetrahydroisoquinoline frameworks.