(S)-N-tosyl-2-acetylamino-1-phenyl-1-methylethanamine | 1085279-19-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-N-tosyl-2-acetylamino-1-phenyl-1-methylethanamine
• 英文别名: N-[(2S)-2-[(4-methylphenyl)sulfonylamino]-2-phenylpropyl]acetamide
• CAS: 1085279-19-1
• 化学式: C₁₈H₂₂N₂O₃S
• 分子量: 346.45
• InChiKey: OVLSRRJQRTUNJO-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  C₁₆H₂₀N₂O₂S 、 乙酸酐 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以7.4 mg的产率得到(S)-N-tosyl-2-acetylamino-1-phenyl-1-methylethanamine
  参考文献：
  名称：

  Highly Enantioselective Aza-Henry Reaction of Ketoimines Catalyzed by Chiral N,N′-Dioxide−Copper(I) Complexes

  摘要：

  The first example of catalytic enantioselective aza-Henry reaction of ketoimines has been realized using a simple chiral N,N'-dioxide-Cu(I) complex as catalyst. It performs well over a range of substrates to give the corresponding products in moderate to good yields (up to 83%) with high enantioselectivities (up to 96% ee).

  DOI：

  10.1021/ol802236h

文献信息

• Highly Enantioselective Aza-Henry Reaction of Ketoimines Catalyzed by Chiral <i>N</i>,<i>N</i>′-Dioxide−Copper(I) Complexes
  作者：Cheng Tan、Xiaohua Liu、Liwei Wang、Jun Wang、Xiaoming Feng

  DOI：10.1021/ol802236h

  日期：2008.11.20

  The first example of catalytic enantioselective aza-Henry reaction of ketoimines has been realized using a simple chiral N,N'-dioxide-Cu(I) complex as catalyst. It performs well over a range of substrates to give the corresponding products in moderate to good yields (up to 83%) with high enantioselectivities (up to 96% ee).