ethyl (Z)-2-methoxy-3-(4-methoxyphenyl)acrylate | 1214260-75-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (Z)-2-methoxy-3-(4-methoxyphenyl)acrylate
• CAS: 1214260-75-9
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: FCFOXKRFOYMQIR-XFXZXTDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.25
• 重原子数：
  17.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  44.76
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  ethyl (Z)-2-methoxy-3-(4-methoxyphenyl)acrylate 在 lithium aluminium tetrahydride 、 氯化铵 作用下， 以 乙醚 、 水 为溶剂， 生成
  参考文献：
  名称：

  New stereospecific synthesis of Tesaglitazar and Navaglitazar precursors

  摘要：

  A new synthetic route of to pharmaceutical intermediates (S)-1a-b and (S)-14 is reported. The reaction pathway is based on the baker's yeast-mediated reduction of the alpha-alkoxy cinnamaldehydes 9a-c to give the corresponding (S)-alcohols in good yields and excellent ee. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.10.027
• 作为产物：
  描述：

  2-methoxy-3-(4-methoxyphenyl)-2-propenoic acid 、 溴乙烷 在 四丁基碘化铵 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 以95%的产率得到ethyl (Z)-2-methoxy-3-(4-methoxyphenyl)acrylate
  参考文献：
  名称：

  New stereospecific synthesis of Tesaglitazar and Navaglitazar precursors

  摘要：

  A new synthetic route of to pharmaceutical intermediates (S)-1a-b and (S)-14 is reported. The reaction pathway is based on the baker's yeast-mediated reduction of the alpha-alkoxy cinnamaldehydes 9a-c to give the corresponding (S)-alcohols in good yields and excellent ee. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.10.027

文献信息

• Stereoselective β‐Arylation of Enol Ethers by a Pd‐Catalyzed Fujiwara‐Moritani Coupling of α‐Oxyacrylates
  作者：Iman Traboulsi、Mahmoud Hachem、Cédric Schneider、Christophe Hoarau

  DOI：10.1002/ejoc.202301074

  日期：2024.1.22

  Herein, Pd(II)‐catalyzed dehydrogenative Heck coupling of 2‐oxyacrylates with arenes for the stereocontrolled production of (Z)‐β‐arylated vinyl ethers is reported. This methodology offers a straightforward and step‐economical route to the synthesis of attractive β‐arylated α‐oxy α,β‐unsaturated carboxylates family which emerged as a relevant class of building blocks with different applications.

  摘要 本文报告了钯(II)催化的 2-氧丙烯酸酯与茴香的脱氢赫克偶联，用于立体控制生产(Z)-β-芳基化乙烯基醚。该方法为合成具有吸引力的 β-芳基化 α-氧基 α,β-不饱和羧酸盐家族提供了一条直接且步骤经济的途径。
• Skin anti-ageing composition
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0688559A1

  公开（公告）日：1995-12-27

  An anti-aging preparation for cutaneous application which prevents cutaneous aging, a collagen cross-linking inhibitory preparation for cutaneous application which inhibits collagen cross-linking occurring predominantly in the dermis to maintain skin elasticity and to prevent wrinkles or sagging, and an anti-UV preparation for cutaneous application which protects the skin from bad influences of excessive ultraviolet rays of sunlight are disclosed. The preparations contain one or two of aminoethyl compounds represented by formula (I):         NH₂CH₂CH₂X   (I) wherein X represents -SO₂H or -SO₂SH, and preferably containing at least one ultraviolet protective agent.

  本发明公开了一种用于皮肤应用的抗衰老制剂，可防止皮肤老化；一种用于皮肤应用的胶原交联抑制制剂，可抑制主要发生在真皮层的胶原交联，以保持皮肤弹性并防止皱纹或松弛；以及一种用于皮肤应用的抗紫外线制剂，可保护皮肤免受过度阳光紫外线的不良影响。这些制剂含有一种或两种由式（I）代表的氨基乙基化合物： NH₂CH₂CH₂X (I) 其中 X 代表-SO₂H 或-SO₂SH、 最好含有至少一种紫外线防护剂。
• Anti-aging cosmetic composition
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0797984A2

  公开（公告）日：1997-10-01

  An anti-aging cosmetic composition in which is blended an enzymolyzed substance obtained by treating by one or more enzymes an alkali extract of a hypoallergenic rice obtained by treating rice in advance with a proteinase and, preferably, a UV protective agent.

  一种抗衰老化妆品组合物，其中掺入了一种酶解物质，这种酶解物质是通过一种或多种酶处理低过敏性大米的碱提取物而获得的，这种低过敏性大米是通过事先用蛋白酶处理大米而获得的，最好还掺入了一种紫外线防护剂。
• AGENTS PROMOTING LAMININ PRODUCTION IN SKIN CELLS
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP1066816A1

  公开（公告）日：2001-01-10

  Disclosed are compositions for promoting the production of laminin 5 in epidermic cells which contain a lysophospholipid having a C14-22 fatty acid residue or a preparation derived from soybeans as an active ingredient and which can be used in the fields of cosmetics and dermatology. These compositions may be used especially for the purpose of potentiating the skin.

  本发明公开了用于促进表皮细胞产生层粘连蛋白 5 的组合物，该组合物含有一种具有 C14-22 脂肪酸残基的溶血磷脂或一种从大豆中提取的制剂作为活性成分，可用于化妆品和皮肤病学领域。这些组合物尤其可用于增强皮肤的功效。
• AGENTS PROMOTING THE FORMATION OF SKIN BASEMENT MEMBRANE, AGENTS PROMOTING THE FORMATION OF ARTIFICIAL SKIN AND PROCESS FOR PRODUCING ARTIFICIAL SKIN
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP1180371A1

  公开（公告）日：2002-02-20

  The present invention discloses an artificial skin formation promoting agent and skin basement membrane stabilizing agent comprising matrix metalloproteinase inhibitor or matrix metalloproteinase inhibitor and matrix protein production promoting agent; as well as a production method of artificial skin comprising adding matrix metalloproteinase inhibitor or matrix metalloproteinase inhibitor and matrix protein production promoting agent to an artificial skin formation medium.

  本发明公开了一种人工皮肤形成促进剂和皮肤基底膜稳定剂，包括基质金属蛋白酶抑制剂或基质金属蛋白酶抑制剂和基质蛋白生成促进剂；以及一种人工皮肤的生产方法，包括在人工皮肤形成介质中加入基质金属蛋白酶抑制剂或基质金属蛋白酶抑制剂和基质蛋白生成促进剂。