<i>N</i>-Protecting group tuning of the enantioselectivity in Strecker reactions of trifluoromethyl ketimines to synthesize quaternary α-trifluoromethyl amino nitriles by ion pair catalysis
作者:Mengyuan Du、Longhui Yu、Ting Du、Zhaokun Li、Yueyang Luo、Xiangyu Meng、Zhengtao Tian、Changwu Zheng、Weiguo Cao、Gang Zhao
DOI:10.1039/c9cc09151c
日期:——
trifluoromethylated quaternary stereocenters with N-PMP and unexplored N-Boc trifluoromethyl ketimines catalyzed using an organophosphine dual-reagent catalyst has been developed. The enantioselectivities of the corresponding products with the same catalyst could be switched by using different N-protecting groups (N-PMP or N-Boc). The trifluoromethyl amino nitriles were obtained in high yield and high enantioselectivity
已开发出一种对映选择性斯特雷克反应,该反应可利用有机膦双试剂催化剂与N-PMP和未探索的N-Boc三氟甲基酮亚胺构建三氟甲基化的季立体中心。可以通过使用不同的N保护基(N-PMP或N-Boc)来切换相应产物与相同催化剂的对映选择性。在短时间内以高收率和高对映选择性获得了三氟甲基氨基腈,并且可以容易地将其转化为多种有用的含三氟甲基的化合物。