(-)-2(S)-Cyclopentylpyrrolidine | 132959-38-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (-)-2(S)-Cyclopentylpyrrolidine
• 英文别名: (s)-2-Cyclopentylpyrrolidine；(2S)-2-cyclopentylpyrrolidine
• CAS: 132959-38-7
• 化学式: C₉H₁₇N
• mdl: MFCD02663460
• 分子量: 139.241
• InChiKey: WXQFEZGWHIDPIP-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (-)-(3R,7aR)-3-Phenyl-5-oxo-7a-cyclopentyl-2,3,5,6,7,7a-hexahydropyrrolo<2,1-b>oxazole 在 palladium on activated charcoal lithium aluminium tetrahydride 、 三氯化铝 、 ammonium formate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 19.0h， 生成 (-)-2(S)-Cyclopentylpyrrolidine
  参考文献：
  名称：

  A simple asymmetric synthesis of 2-substituted pyrrolidines from 3-acylpropionic acids

  摘要：

  The title compounds have been prepared from 3-acylpropionic acids 2 and (-)-R-phenylglycinol in a three-step sequence in > 98% enantiomeric excess. The R group in 2 ultimately becomes the 2-substituent in the chiral pyrrolidine.

  DOI：

  10.1021/jo00007a011

文献信息

• Bicyclic derivatives as CETP inhibitors
  申请人：Kishida Masashi

  公开号：US20090227580A1

  公开（公告）日：2009-09-10

  The present invention relates to novel compounds of formula (I) or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay progression to overt to diseases in which CETP is involved.

  本发明涉及式(I)的新化合物或其药物组合物，其中所有变量在文本中定义。本发明进一步涉及使用本发明中的化合物治疗或延缓与CETP有关的疾病的进展。
• CETP inhibitors
  申请人：Sakaki Junichi

  公开号：US20090075968A1

  公开（公告）日：2009-03-19

  The present invention relates to a compound of formula or a pharmaceutically acceptable salt thereof, wherein the variables are as defined.

  本发明涉及一种化合物的公式或其药学上可接受的盐，其中变量的定义如下。
• BICYCLIC DERIVATIVES AS CETP INHIBITORS
  申请人：KISHIDA Masashi

  公开号：US20120225874A1

  公开（公告）日：2012-09-06

  The present invention relates to novel compounds of formula (I) or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay progression to overt to diseases in which CETP is involved.

  本发明涉及公式（I）的新化合物或其药物组成物，其中所有变量在文本中定义。本发明还涉及将本化合物用于治疗或延缓CETP参与的疾病的进展。
• A simple asymmetric synthesis of 2-substituted pyrrolidines and 5-substituted pyrrolidinones
  作者：Laurence E. Burgess、A. I. Meyers

  DOI：10.1021/jo00032a012

  日期：1992.3

  An efficient procedure for the preparation of the title compounds in high enantiomeric purity has been realized starting from 3-acylpropionic acids. Stereoselective reduction of chiral bicyclic lactams 2a-h, prepared from the corresponding gamma-keto acid and (R)-phenylglycinol, using alane or triethylsilane with titanium tetrachloride provided the N-substituted pyrrolidines and pyrrolidinones, respectively. Subsequent cleavage of the phenylglycinol returned the desired amines and lactams. The enantiomeric purity of these compounds was determined to be > 98% by chiral stationary-phase HPLC.
• MEYERS, A. I.;BURGESS, LAURENCE E., J. ORG. CHEM., 56,(1991) N, C. 2294-2296
  作者：MEYERS, A. I.、BURGESS, LAURENCE E.

  DOI：——

  日期：——