N-(2-叠氮苯基)琥珀酰亚胺 | 1018-52-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: N-(2-叠氮苯基)琥珀酰亚胺
• 英文名称: N-(2-azidophenyl)succinimide
• 英文别名: N-(2-Azidophenyl)-succinimid；1-(2-Azidophenyl)pyrrolidine-2,5-dione
• CAS: 1018-52-6
• 化学式: C₁₀H₈N₄O₂
• 分子量: 216.199
• InChiKey: XDQZJAQOLXSIGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  51.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(2-叠氮苯基)琥珀酰亚胺 在 亚磷酸三乙酯 作用下， 以 甲苯 为溶剂， 以53%的产率得到2,3-dihydro-1H-pyrrolo<1,2-a>benzimidazole-1-one
  参考文献：
  名称：

  Heterocycles by intramolecular aza-Wittig reactions of iminophosphoranes obtained from 2-azidobenzoyl- and 2-azidobenzylidene derivatives

  摘要：

  DOI：

  10.1016/s0040-4039(00)97117-x

文献信息

• LUHESHI, ABDUL-BASSETT N.;SALEM, SALEM M.;SMALLEY, ROBERT K.;KENNEWELL, P+, TETRAHEDRON LETT., 31,(1990) N5, C. 6561-6564
  作者：LUHESHI, ABDUL-BASSETT N.、SALEM, SALEM M.、SMALLEY, ROBERT K.、KENNEWELL, P+

  DOI：——

  日期：——
• KREHER R.; BERGMANN U., Z. NATURFORSCH. <ZENB-AX>, 1976, 31B, NO 2, 222-226
  作者：KREHER R.、 BERGMANN U.

  DOI：——

  日期：——
• PROSTATE SPECIFIC ANTIGENS, CONJUGATES THEREOF, METHODS FOR THEIR PREPARATION AND USES THEREOF.
  申请人：Sloan-Kettering Institute For Cancer Research

  公开号：EP1570056A2

  公开（公告）日：2005-09-07
• [EN] PROSTATE SPECIFIC ANTIGENS, CONJUGATES THEREOF, METHODS FOR THEIR PREPARATION AND USES THEREOF.<br/>[FR] ANTIGENES SPECIFIQUES DE LA PROSTATE, CONJUGUES DE CES ANTIGENES, PROCEDES CORRESPONDANTS D'ELABORATION ET D'UTILISATION
  申请人：SLOAN KETTERING INST CANCER

  公开号：WO2004060915A2

  公开（公告）日：2004-07-22

  The present invention provides compounds having formula (I): wherein W1, W2, R1, R3, R4, R2A and R2B are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods of use thereof in the treatment of cancer, methods for the prevention of recurrence of cancer, and methods for inducing antibodies in a subject, comprising administering to a subject in need thereof, an effective amount of any of the inventive compounds as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier. In another aspect, the invention provides an antibody or antibody fragment which binds specifically to a normal or transformed PSA glycan or glycopeptide of the invention. In another aspect, the invention provides an immunoassay method for the quantitative determination of normal or transformed PSA in a biological sample. In another aspect, the invention provides an immunoassay kit for assessing the presence and/or amount of normal or transformed PSA in a sample. In another aspect, the invention provides a diagnostic kit for diagnosing an adenocarcinoma of the prostate in an individual suspected of suffering therefrom, or for differentiating between a benign pathology of the prostate and an adenocarcinoma of the prostate in an individual suspected of suffering therefrom.