(S)-4-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-[4-methyl-6-(2-methoxy-ethoxy)-1H-benzimidazol-2-yl]-1H-pyridin-2-one | 468740-76-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: (S)-4-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-[4-methyl-6-(2-methoxy-ethoxy)-1H-benzimidazol-2-yl]-1H-pyridin-2-one
• 英文别名: 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-(2-methoxyethoxy)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridin-2-one
• CAS: 468740-76-3
• 化学式: C₂₄H₂₅ClN₄O₄
• 分子量: 468.94
• InChiKey: CJCXXSGEMIIROV-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  109
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Novel tyrosine kinase inhibitors
  申请人：——

  公开号：US20040044203A1

  公开（公告）日：2004-03-04

  The present invention provides compounds of formula I 1 and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.

  本发明提供了公式I1的化合物及其药用盐。公式I化合物抑制酪氨酸激酶酶，因此可用作抗癌剂。公式I化合物还可用于治疗其他可以通过抑制酪氨酸激酶酶来治疗的疾病。
• Synergistic methods and compositions for treating cancer
  申请人：——

  公开号：US20040209930A1

  公开（公告）日：2004-10-21

  Combination therapies using IGF1R inhibitors in combination with additional kinase inhibitors are described for the synergistic treatment of cancer.

  描述了使用IGF1R抑制剂与其他激酶抑制剂结合的联合疗法，用于癌症的协同治疗。
• Methods for treating IGF1R-inhibitor induced hyperglycemia
  申请人：Carboni M. Joan

  公开号：US20050075358A1

  公开（公告）日：2005-04-07

  Methods for treating cancer using IGF1R inhibitors in combination with insulin sensitizers are provided for the treatment or prevention of hyperglycemia.

  提供了使用 IGF1R 抑制剂与胰岛素增敏剂联合治疗癌症的方法，以治疗或预防高血糖症。
• Tire with shock absorbing closed cell rubber tread of spaced apart lugs
  申请人：Lukich Timothy Lewis

  公开号：US20050103415A1

  公开（公告）日：2005-05-19

  The invention relates to a pneumatic rubber tire having an outer, circumferential tread wherein said tread has a tread configuration comprised of significantly spaced apart, raised lugs designed to be shock absorbingly ground engaging. For such tire, it is intended that, in the field, normally few tread lugs actually engage the ground at any one time in a manner that individual lugs have a relatively significant shock absorbing responsibility. Said tread and associated tread lugs are comprised of a shock dampening closed cellular rubber composition. The rubber for such cellular rubber composition for said tread of spaced apart lugs is comprised of conjugated diene-based elastomers or comprised of elastomers selected from butyl rubber, halogenated butyl rubber or brominated copolymer of isobutylene and paramethylstyrene rubber. Said butyl rubber is a copolymer of isobutylene and a minor amount of a diene monomer such as isoprene. Preferably the rubber for the cellular tread rubber composition is an isobutylene copolymer. Thus, such tread is a combination of structural configuration of spaced apart lugs together with a closed cellular rubber composition of selected elastomer(s) to create a shock absorbing effect for the tire tread lugs.

  本发明涉及一种充气橡胶轮胎，该轮胎具有外侧圆周胎面，其中所述胎面具有由明显间隔开的凸起胎耳组成的胎面结构，其设计目的是吸收地面冲击。对于这种轮胎，其设计意图是，在现场，通常很少有胎面凸耳在任何时候以单个凸耳具有相对重要的减震作用的方式实际与地面啮合。所述胎面和相关胎耳由减震封闭式蜂窝橡胶组合物组成。用于所述胎面间隔耳的蜂窝橡胶组合物的橡胶由共轭二烯基弹性体组成，或由选自丁基橡胶、卤化丁基橡胶或异丁烯和对甲基苯乙烯橡胶的溴化共聚物的弹性体组成。所述丁基橡胶是异丁烯与少量异戊二烯等二烯单体的共聚物。用于蜂窝胎面橡胶组合物的橡胶最好是异丁烯共聚物。因此，这种胎面是由间隔开的胎耳结构配置与选定弹性体组成的封闭式蜂窝橡胶组合而成，为轮胎胎面的胎耳产生减震效果。
• NOVEL TYROSINE KINASES INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1545543A2

  公开（公告）日：2005-06-29