2-(2-hydroxycyclohexyloxy)benzaldehyde | 1183032-92-9

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 2-(2-hydroxycyclohexyloxy)benzaldehyde
• 英文别名: 2-(2-Hydroxycyclohexyl)oxybenzaldehyde
• CAS: 1183032-92-9
• 化学式: C₁₃H₁₆O₃
• 分子量: 220.268
• InChiKey: RLUVSHPORZFRDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-hydroxycyclohexyloxy)benzaldehyde 在 4-methyl-3-(2,4,6-trimethylphenyl)thiazolium perchlorate 、 三乙胺 、 偶氮苯 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 以78%的产率得到7,8,9,9a-tetrahydro-5aH-dibenzo[b,e][1,4]dioxepin-11(6H)-one
  参考文献：
  名称：

  Efficient Catalytic, Oxidative Lactonization for the Synthesis of Benzodioxepinones Using Thiazolium-Derived Carbene Catalysts

  摘要：

  An efficient, oxidative carbene-catalyzed lactonization reaction has been developed. Using thiazolium precatalysts, a variety of benzodioxepinone products are accessible in good to excellent yields under mild and operationally simple conditions The reaction does not require high dilution conditions and proceeds via mild and selective oxidation with azobenzene, which can easily be recovered and reused applying inexpensive FeCl3 as a formal terminal oxidant

  DOI：

  10.1021/ol101854r

文献信息

• CYCLOALKOXY-SUBSTITUTED 4-PHENYL-3,5-DICYANOPYRIDINES AND THEIR USE
  申请人：Hübsch Walter

  公开号：US20110021487A1

  公开（公告）日：2011-01-27

  The present application relates to novel cycloalkoxy-substituted 4-phenyl-3,5-dicyanopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.

  本申请涉及新型环烷氧基取代的4-苯基-3,5-二氰基吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途以及其用于制备治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防心血管和代谢性疾病。