3-ethyl-2H-pyrrolo[2,1-a]isoindole-2,5(3H)dione | 1167995-41-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 3-ethyl-2H-pyrrolo[2,1-a]isoindole-2,5(3H)dione
• 英文别名: 3-ethyl-3H-pyrrolo[1,2-b]isoindole-2,5-dione
• CAS: 1167995-41-6
• 化学式: C₁₃H₁₁NO₂
• 分子量: 213.236
• InChiKey: UHKKHPGSWXGKAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  碘乙烷 、 2,3-Dihydro-5H-pyrrolo<1,2-a>isoindole-2,5-dione 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以79%的产率得到3-ethyl-2H-pyrrolo[2,1-a]isoindole-2,5(3H)dione
  参考文献：
  名称：

  Efficient Horner–Wadsworth–Emmons intramolecular cyclisation of a N-substituted phthalimide promoted by KF-Alumina: a general tool for the synthesis of functionalised isoindolinones

  摘要：

  An intramolecular Horner-Wadsworth-Emmons reaction promoted by KF-Alumina involving a N-substituted phthalimide, cleanly and efficiently furnishes an interesting alpha,beta-unsaturated tricyclic enone which may undergo selective alkylations at the alpha'-position. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.029

文献信息

• Efficient Horner–Wadsworth–Emmons intramolecular cyclisation of a N-substituted phthalimide promoted by KF-Alumina: a general tool for the synthesis of functionalised isoindolinones
  作者：Vittorio Pace、Fernando Martínez、Clara I. Nova、María Fernández、José Vicente Sinisterra、Andrés R. Alcántara

  DOI：10.1016/j.tetlet.2009.04.029

  日期：2009.6

  An intramolecular Horner-Wadsworth-Emmons reaction promoted by KF-Alumina involving a N-substituted phthalimide, cleanly and efficiently furnishes an interesting alpha,beta-unsaturated tricyclic enone which may undergo selective alkylations at the alpha'-position. (C) 2009 Elsevier Ltd. All rights reserved.