N-[4-[17-[4-[benzoyl(hydroxy)amino]phenyl]-25,26,27,28-tetrahydroxy-11,23-bis(4-nitrophenyl)-2,8,14,20-tetrathiapentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaen-5-yl]phenyl]-N-hydroxybenzamide | 1051911-81-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-[17-[4-[benzoyl(hydroxy)amino]phenyl]-25,26,27,28-tetrahydroxy-11,23-bis(4-nitrophenyl)-2,8,14,20-tetrathiapentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaen-5-yl]phenyl]-N-hydroxybenzamide
• CAS: 1051911-81-9
• 化学式: C₆₂H₄₀N₄O₁₂S₄
• 分子量: 1161.28
• InChiKey: AJNZMYLLVXDGNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.1
• 重原子数：
  82
• 可旋转键数：
  8
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  355
• 氢给体数：
  6
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  、 苯甲酰氯 在 sodium carbonate 作用下， 反应 0.05h， 以91%的产率得到N-[4-[17-[4-[benzoyl(hydroxy)amino]phenyl]-25,26,27,28-tetrahydroxy-11,23-bis(4-nitrophenyl)-2,8,14,20-tetrathiapentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaen-5-yl]phenyl]-N-hydroxybenzamide
  参考文献：
  名称：

  Synthesis of Thia-calix[4]arene Hydroxamic Acids by Microwave Irradiation

  摘要：

  Thia-calix[4]arene hydroxamic acids have been synthesized by partial reduction of nitro-thia-calix[4]arenes with hydrazine hydrate, Rn/Ni, and their coupling with benzoyl chloride under the influence of microwave irradiation with 90-95% yield and 3-6min reaction time.

  DOI：

  10.1080/00397910802139429

文献信息

• Synthesis of Thia-calix[4]arene Hydroxamic Acids by Microwave Irradiation
  作者：Y. K. Agrawal、J. P. Pancholi

  DOI：10.1080/00397910802139429

  日期：2008.6.27

  Thia-calix[4]arene hydroxamic acids have been synthesized by partial reduction of nitro-thia-calix[4]arenes with hydrazine hydrate, Rn/Ni, and their coupling with benzoyl chloride under the influence of microwave irradiation with 90-95% yield and 3-6min reaction time.