(2R,5S)-10-ethoxycarbonyl-11-oxo-2,8,9-triphenyl-1,8-diaza-3,7-dioxa-tricyclo[6.3.0^1,5.0^6,10]undecane | 195874-16-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (2R,5S)-10-ethoxycarbonyl-11-oxo-2,8,9-triphenyl-1,8-diaza-3,7-dioxa-tricyclo[6.3.0^1,5.0^6,10]undecane
• 英文别名: ethyl (1R,9R)-7-oxo-4,5,9-triphenyl-3,10-dioxa-4,8-diazatricyclo[6.3.0.02,6]undecane-6-carboxylate
• CAS: 195874-16-9
• 化学式: C₂₈H₂₆N₂O₅
• 分子量: 470.525
• InChiKey: VCTXNBJNNDXCLB-VERQUZQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2R,5S)-10-ethoxycarbonyl-11-oxo-2,8,9-triphenyl-1,8-diaza-3,7-dioxa-tricyclo[6.3.0^1,5.0^6,10]undecane 以 甲苯 为溶剂， 反应 8.0h， 生成 (2R,5S,6S,9S,10S)-10-ethoxycarbonyl-11-oxo-2,8,9-triphenyl-1,8-diaza-3,7-dioxa-tricyclo[6.3.0^1,5.0^6,10]undecane
  参考文献：
  名称：

  Functionalised pyrrolidinones derived from (S)-pyroglutamic acid by cycloaddition reactions

  摘要：

  The alpha,beta-unsaturated bicyclic lactams 3a,c, prepared from (S)-pyroglutamic acid, are useful substrates for cycloaddition reactions, giving excellent regio-and diastereocontrol; however, lactam 3c has very superior reactivity with several dienes and dipoles under mild reaction conditions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00740-0
• 作为产物：
  描述：

  (3R,7aS)-5-Oxo-3-phenyl-6-phenylselanyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester 在 双氧水 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 24.5h， 生成 (2R,5S)-10-ethoxycarbonyl-11-oxo-2,8,9-triphenyl-1,8-diaza-3,7-dioxa-tricyclo[6.3.0^1,5.0^6,10]undecane
  参考文献：
  名称：

  Functionalised pyrrolidinones derived from (S)-pyroglutamic acid by cycloaddition reactions

  摘要：

  The alpha,beta-unsaturated bicyclic lactams 3a,c, prepared from (S)-pyroglutamic acid, are useful substrates for cycloaddition reactions, giving excellent regio-and diastereocontrol; however, lactam 3c has very superior reactivity with several dienes and dipoles under mild reaction conditions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00740-0

文献信息

• Functionalised pyrrolidinones derived from (S)-pyroglutamic acid by cycloaddition reactions
  作者：Jonathan H. Bailey、David T. Cherry、Katherine M. Crapnell、Mark G. Moloney、Sung Bo Shim、Mark J. Bamford、R.Brian Lamont

  DOI：10.1016/s0040-4020(97)00740-0

  日期：1997.8

  The alpha,beta-unsaturated bicyclic lactams 3a,c, prepared from (S)-pyroglutamic acid, are useful substrates for cycloaddition reactions, giving excellent regio-and diastereocontrol; however, lactam 3c has very superior reactivity with several dienes and dipoles under mild reaction conditions. (C) 1997 Elsevier Science Ltd.