1-Methyl-1H-benzimidazol-3-ium Trifluoromethanesulfonate | 361447-89-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-Methyl-1H-benzimidazol-3-ium Trifluoromethanesulfonate
• 英文别名: 3-methyl-1H-benzimidazol-3-ium;trifluoromethanesulfonate
• CAS: 361447-89-4
• 化学式: C9H9F3N2O3S
• 分子量: 282.24
• InChiKey: SLCPRHIKNIDSJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.97
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  80.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS<br/>[FR] SYNTHÈSE DIRIGÉE DE STÉRÉOISOMÈRES D'OLIGOPHOSPHORAMIDATES
  申请人：ROCHE DIAGNOSTICS GMBH

  公开号：WO2010060599A1

  公开（公告）日：2010-06-03

  The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula (1) are produced in a stereocontrolled manner.

  化合物中的三价磷原子与试剂反应，形成稳定的磷酸盐类似物或特异性物质。为此，具有至少一个含有保护基的氢氧基的含磷原子的磷酰胺酯与自由氢氧基反应：在第一个合成循环中，通过可裂解或不可裂解的连接剂将氢氧基与固体支持物连接。在进一步的合成循环中，通过从生长寡聚物中裂解保护基来创建氢氧基。这导致形成磷酸三酯，然后与叠氮化物反应。通过选择合适的单体进行合成，这些单体具有定义的立体构型，从而以立体控制的方式产生式（1）的化合物。
• Method for synthesizing cyclic bisdinucleoside
  申请人：Hayakawa Yoshihiro

  公开号：US20060167241A1

  公开（公告）日：2006-07-27

  A compound represented by Formula [2]: wherein R 2 and R 3 each independently represent a hydrogen atom, a halogen atom, a methoxy group, a 2-methoxyethoxy group or a hydroxyl group; and B 2 and B 3 each independently represent a nucleic acid base, or a salt thereof can be synthesized from a compound represented by Formula [1]: wherein R 1 represents a hydrogen atom, a halogen atom, a methoxy group, a 2-methoxyethoxy group, or a hydroxyl group substituted with a hydroxyl protecting group; and B 1 represents a nucleic acid base which may be protected.

  化合物的化学式为[2]，其中R2和R3各自独立地表示氢原子、卤素原子、甲氧基、2-甲氧基乙氧基或羟基；B2和B3各自独立地表示核酸碱基或其盐。该化合物可以从化学式[1]表示的化合物合成，其中R1表示氢原子、卤素原子、甲氧基、2-甲氧基乙氧基或羟基，且带有羟基保护基；B1表示可能被保护的核酸碱基。
• METHOD OF SYNTHESIZING CYCLIC BISDINUCLEOSIDE
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1645561A1

  公开（公告）日：2006-04-12

  A compound represented by Formula [2]: wherein R2 and R3 each independently represent a hydrogen atom, a halogen atom, a methoxy group, a 2-methoxyethoxy group or a hydroxyl group; and B2 and B3 each independently represent a nucleic acid base, or a salt thereof can be synthesized from a compound represented by Formula [1]: wherein R1 represents a hydrogen atom, a halogen atom, a methoxy group, a 2-methoxyethoxy group, or a hydroxyl group substituted with a hydroxyl protecting group; and B1 represents a nucleic acid base which may be protected.

  由式 [2] 表示的化合物： 其中 R2 和 R3 各自独立地代表氢原子、卤素原子、甲氧基、2-甲氧基乙氧基或羟基；以及 B2 和 B3 各自独立地代表核酸碱基、 或其盐可以由式 [1] 所代表的化合物合成： 其中 R1 代表氢原子、卤素原子、甲氧基、2-甲氧基乙氧基或被羟基保护基取代的羟基；B1 代表可被保护的核酸碱基。
• METHOD FOR PRODUCING RNA
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP3950695A1

  公开（公告）日：2022-02-09

  The present invention provides a method for preparing RNA by a phosphoramidite solid-phase synthesis using an porous inorganic carrier containing a primary amino group, the method being able to bring about an increased purity even in the synthesis of medium-stranded to long-stranded RNA. In the method for producing RNA, an amount of the primary amino group contained in the porous inorganic carrier satisfies the following formula (1): 0.7 ≤ (I × R)/S ≤ 1.8 [wherein, I is an amount of the amino group per unit mass of the porous inorganic carrier (µmol/g), as measured by a 2-nitrobenzenesulfonic acid adsorption method; R is a ratio of the primary amino group in the total amino groups contained in the porous inorganic carrier (amount of primary amino group/amount of total amino groups); and S is a specific surface area (m2/g) of the porous inorganic carrier as measured by a nitrogen adsorption method].

  本发明提供了一种利用含有伯氨基的多孔无机载体通过磷酰胺固相合成制备RNA的方法，该方法即使在合成中链至长链RNA时也能提高纯度。在生产 RNA 的方法中，多孔无机载体中所含伯氨基的量满足下式（1）：0.7 ≤ (i × r)/s ≤ 1.8 [其中，I 为多孔无机载体每单位质量中的氨基量（微摩尔/克），以 2-硝基苯磺酸吸附法测定；R 为多孔无机载体中所含主氨基在总氨基中的比例（主氨基量/总氨基量）；S 为多孔无机载体的比表面积（平方米/克），以氮吸附法测定]。
• INORGANIC POROUS SUPPORT AND METHOD FOR PRODUCING NUCLEIC ACID USING SAME
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP3950124A1

  公开（公告）日：2022-02-09

  The present invention provides: an inorganic porous carrier that can be used to increase the purity of nucleic acid in a production thereof, and that comprises a linker represented by general formula (1), wherein a Survival Bone Rate (SBR) value is 5.0 % or more [in the formula (1), a bond marked with * represents a linkage of an inorganic porous substance to the oxygen atom of a silanol group; n is an integer of 1 etc.; R represents independently of each other an alkyl group containing 3 to 10 carbon atoms which may optionally have a substituent such as an alkoxy group etc.; and L represents a single bond; an alkylene group of 1 to 20 carbon atoms; or an alkylene group containing 2 to 20 carbon atoms which contains -CH2-Q-CH2- group wherein any group Q selected from a group consisting of -O- etc. is inserted into at least one of -CH2-CH2- group constituting the alkylene group]; and a method for preparing a nucleic acid using the same.

  本发明提供了：一种无机多孔载体，可用于提高核酸生产中的核酸纯度，该载体包括通式（1）表示的连接体，其中存活骨率（SBR）值为5.0%或以上[在式（1）中，标有*的键代表无机多孔物质与硅烷醇基的氧原子的连接；n为1等的整数。R相互独立地代表含 3 至 10 个碳原子的烷基，该烷基可任选具有取代基，如烷氧基等；L代表单键；含 1 至 20 个碳原子的亚烷基；或含 2 至 20 个碳原子的亚烷基，该亚烷基含有-CH2-Q- -基团，其中从-O-等组成的组中选出的任一基团 Q 插入到构成亚烷基的- - -基团中的至少一个基团中]；以及用其制备核酸的方法。