N-(2-hydroxyethyl)-N-methyl-β-alanine | 124335-43-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-hydroxyethyl)-N-methyl-β-alanine
• 英文别名: 3-[2-Hydroxyethyl(methyl)azaniumyl]propanoate
• CAS: 124335-43-9
• 化学式: C₆H₁₃NO₃
• mdl: MFCD09716816
• 分子量: 147.174
• InChiKey: QEBLLSSGRQCVJI-UHFFFAOYSA-N

物化性质

• 沸点：
  295.5±20.0 °C(Predicted)
• 密度：
  1.159±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  64.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-hydroxyethyl)-N-methyl-β-alanine 、 [4-(Dodecanoyloxymethyl)piperidin-4-yl]methyl dodecanoate 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以19%的产率得到[4-(Dodecanoyloxymethyl)-1-[3-[2-hydroxyethyl(methyl)amino]propanoyl]piperidin-4-yl]methyl dodecanoate
  参考文献：
  名称：

  [EN] LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS
  [FR] COMPOSÉS LIPIDIQUES ET COMPOSITIONS DE NANOPARTICULES LIPIDIQUES

  摘要：

  本文提供了一种脂质化合物，可与其他脂质成分（如中性脂质、胆固醇和聚合物共轭脂质）结合使用，形成脂质纳米粒子，用于传递治疗剂（如核酸分子）以进行治疗或预防，包括疫苗接种。本文还提供了包含所述脂质化合物的脂质纳米粒子组合物。

  公开号：

  WO2022037652A1
• 作为产物：
  描述：

  N-Methyl-N-(2-hydroxyethyl)-β-alanin-methylester 在 lithium hydroxide monohydrate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 2.0h， 生成 N-(2-hydroxyethyl)-N-methyl-β-alanine
  参考文献：
  名称：

  [EN] LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS
  [FR] COMPOSÉS LIPIDIQUES ET COMPOSITIONS DE NANOPARTICULES LIPIDIQUES

  摘要：

  本文提供了一种脂质化合物，可与其他脂质成分（如中性脂质、胆固醇和聚合物共轭脂质）结合使用，形成脂质纳米粒子，用于传递治疗剂（如核酸分子）以进行治疗或预防，包括疫苗接种。本文还提供了包含所述脂质化合物的脂质纳米粒子组合物。

  公开号：

  WO2022037652A1

文献信息

• Hair cosmetic, aminocarboxylic acid amide and method for producing the same
  申请人：Kao Corporation

  公开号：US20030035784A1

  公开（公告）日：2003-02-20

  A hair cosmetic which can impart, to hairs, flexibility, smoothness and oily feeling when the hairs are wetted and smoothness, softness and combing easiness after the hairs are dried are provided, the hair cosmetic comprising an amine represented by the formula (I): Formula (I) 1 (wherein R 1 represents a C 8-40 alkyl group or alkenyl group or a group represented by the formula R 5 O—(AO) n —C m H 2m — (R 5 represents a C 8-40 alkyl group or alkenyl group having 8 to 40 carbon atoms, A represents a C 2-3 alkylene group, n denotes a number from 0 to 30 in average and m denotes an integer of 2 or 3), R 2 represents a C 1-5 alkylene group, R 3 represents H, a C 1-24 alkyl group, alkenyl group or hydroxyalkyl group or a C 6-28 aryl group or arylalkyl group, R 4 represents H, a C 1-5 alkyl group, alkylene group or hydroxyalkyl group or a C 6-28 aryl group or arylalkyl group, p denotes an integer from 1 to 3, q and r denote integers from 0 to 2 and p+q+r is equal to 3. Also, the amine (I) can be produced with high selectivity and highly economically by reacting a primary amine with an aminocarboxylic acid to run amidation. An amine represented by the formula (1), its salt or quaternary ammonium salt are also provided: Formula (1) 2

  提供一种头发化妆品，它可以在头发被浸湿时赋予头发柔软、光滑和油腻的感觉，并在头发干燥后提供光滑、柔软和易于梳理的效果。该头发化妆品包括一种由式(I)表示的胺：式(I)1（其中，R1表示C8-40烷基或烯基或由式R5O-（AO）n-CmH2m-表示的基团（其中，R5表示具有8至40个碳原子的C8-40烷基或烯基，A表示C2-3烷基，n表示平均值为0至30的数字，m表示2或3的整数），R2表示C1-5烷基，R3表示H、C1-24烷基、烯基或羟基烷基或C6-28芳基基团或芳基烷基基团，R4表示H、C1-5烷基、烷基或羟基烷基或C6-28芳基基团或芳基烷基基团，p表示1至3的整数，q和r表示0至2的整数，且p+q+r等于3。此外，胺（I）可以通过将一种一级胺与一种氨基羧酸反应以进行酰胺化，从而高选择性、高经济性地生产。还提供一种由式（1）表示的胺、其盐或季铵盐：式（1）2。
• S1P receptor modulating compounds and use thereof
  申请人：Burli Roland

  公开号：US20080027036A1

  公开（公告）日：2008-01-31

  The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.

  本发明涉及一般式（I）的化合物，其具有作为S1P受体调节剂的活性，以及使用这种化合物来治疗与不适当的S1P受体活性相关的疾病。这些化合物可以用作免疫调节剂，例如，用于治疗或预防自身免疫和相关免疫紊乱疾病，包括系统性红斑狼疮、炎症性肠病，如克隆病和溃疡性结肠炎、1型糖尿病、葡萄膜炎、牛皮癣、重症肌无力、类风湿性关节炎、非肾小球性肾病、肝炎、Behçet病、肾小球肾炎、慢性血小板减少性紫癜、溶血性贫血、肝炎和Wegner肉芽肿；以及用于治疗其他疾病。
• S1P Receptor Modulating Compounds and Use Thereof
  申请人：Saha Ashis K.

  公开号：US20110059945A1

  公开（公告）日：2011-03-10

  The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.

  本发明涉及一般式（I）的化合物，其具有作为S1P受体调节剂的活性，以及使用这些化合物治疗与不适当的S1P受体活性相关的疾病。这些化合物可用作免疫调节剂，例如，用于治疗或预防自身免疫和相关免疫性疾病，包括全身性红斑狼疮、克罗恩病和溃疡性结肠炎、I型糖尿病、葡萄膜炎、银屑病、重症肌无力、类风湿性关节炎、非肾小球性肾病、肝炎、Behçet病、肾小球肾炎、慢性血小板减少性紫癜、溶血性贫血、肝炎和Wegner肉芽肿；以及用于治疗其他疾病。
• FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
  申请人：BIOMATRICA, INC.

  公开号：US20150329849A1

  公开（公告）日：2015-11-19

  Described herein are stabilized polymerase compositions comprising a polymerase and an polymerase stabilizing agent, such as a non-detergent zwitterionic stabilizer or a cationic ester disclosed, for use in nucleic acid amplification or nucleic acid sequencing. Compositions are provided for the stabilization of one or more polymerases in a single stabilized liquid formulation. Also disclosed are methods for making and using stabilized polymerase compositions and kits for nucleic acid amplification and sequencing comprising the stabilized polymerase compositions provided.

  本文描述了稳定的聚合酶组合物，包括聚合酶和聚合酶稳定剂，例如非离子洗涤剂双性稳定剂或阳离子酯类稳定剂，用于核酸扩增或核酸测序。提供了用于单个稳定液体配方中稳定一个或多个聚合酶的组合物。还公开了制备和使用稳定聚合酶组合物的方法以及包含所提供的稳定聚合酶组合物的核酸扩增和测序试剂盒。
• IONIZABLE CATIONIC LIPIDS AND LIPID NANOPARTICLES, AND METHODS OF SYNTHESIS AND USE THEREOF
  申请人：Tidal Therapeutics, Inc.

  公开号：US20220218614A1

  公开（公告）日：2022-07-14

  Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

  提供了可离子化阳离子脂质和脂质纳米粒子，用于将核酸输送到细胞（例如免疫细胞），以及制备和使用此类脂质和靶向脂质纳米粒子的方法。