2-Chloro-3'-cyclopentyloxy-4'-methoxy-biphenyl-4-carboxylic acid | 189254-77-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Chloro-3'-cyclopentyloxy-4'-methoxy-biphenyl-4-carboxylic acid
• CAS: 189254-77-1
• 化学式: C₁₉H₁₉ClO₄
• 分子量: 346.81
• InChiKey: GEPSVYYYTYZLAX-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-Chloro-3'-cyclopentyloxy-4'-methoxy-biphenyl-4-carboxylic acid 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 2-Chloro-3'-cyclopentyloxy-4'-methoxy-biphenyl-4-carbonyl chloride
  参考文献：
  名称：

  Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-α

  摘要：

  Tumor necrosis factor-alpha (TNF-alpha) has been implicated as a key mediator in the progression of rheumatoid arthritis. Inhibitors of phosphodiesterase IV (PDE IV) have been shown to inhibit the production of TNF-alpha by elevating intracellular levels of cyclic adenosine monophosphate (cAMP). Our efforts in a series of biarylcarboxamides have led to the identification of 8j (CP-353,164) as a potent inhibitor of PDE IV and TNF-alpha production. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00097-8
• 作为产物：
  描述：

  2-Chloro-3'-cyclopentyloxy-4'-methoxy-biphenyl-4-carboxylic acid methyl ester 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 2-Chloro-3'-cyclopentyloxy-4'-methoxy-biphenyl-4-carboxylic acid
  参考文献：
  名称：

  Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-α

  摘要：

  Tumor necrosis factor-alpha (TNF-alpha) has been implicated as a key mediator in the progression of rheumatoid arthritis. Inhibitors of phosphodiesterase IV (PDE IV) have been shown to inhibit the production of TNF-alpha by elevating intracellular levels of cyclic adenosine monophosphate (cAMP). Our efforts in a series of biarylcarboxamides have led to the identification of 8j (CP-353,164) as a potent inhibitor of PDE IV and TNF-alpha production. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00097-8