2-(5-azidomethyl-3-isobutyl-2-(4-(trifluoromethyl)benzyl)isoxazolidin-3-yl)ethanol | 1427514-59-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(5-azidomethyl-3-isobutyl-2-(4-(trifluoromethyl)benzyl)isoxazolidin-3-yl)ethanol
• 英文别名: 2-[(3S,5R)-5-(azidomethyl)-3-(2-methylpropyl)-2-[[4-(trifluoromethyl)phenyl]methyl]-1,2-oxazolidin-3-yl]ethanol
• CAS: 1427514-59-7
• 化学式: C₁₈H₂₅F₃N₄O₂
• 分子量: 386.417
• InChiKey: UVIINUXOGNVDJV-IAGOWNOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  47.1
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-(5-azidomethyl-3-isobutyl-2-(4-(trifluoromethyl)benzyl)isoxazolidin-3-yl)ethanol 在 水 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics

  摘要：

  Small molecules that mimic the transcriptional activation domain of eukaryotic transcriptional activators have the potential to serve as effective inhibitors of transcriptional processes. Here we show that one class of transcriptional activation domain mimics, amphipathic isoxazolidines, can be converted into inhibitors of gene expression mediated by the transcriptional activator ESX through small structural modi. cations. Addition of the small molecules leads to decreased expression of the cell surface growth receptor ErbB2(Her2) in ErbB2-positive cancer cells and, correspondingly, decreased proliferation. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.090
• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 以42 mg的产率得到2-(5-azidomethyl-3-isobutyl-2-(4-(trifluoromethyl)benzyl)isoxazolidin-3-yl)ethanol
  参考文献：
  名称：

  Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics

  摘要：

  Small molecules that mimic the transcriptional activation domain of eukaryotic transcriptional activators have the potential to serve as effective inhibitors of transcriptional processes. Here we show that one class of transcriptional activation domain mimics, amphipathic isoxazolidines, can be converted into inhibitors of gene expression mediated by the transcriptional activator ESX through small structural modi. cations. Addition of the small molecules leads to decreased expression of the cell surface growth receptor ErbB2(Her2) in ErbB2-positive cancer cells and, correspondingly, decreased proliferation. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.090

文献信息

• [EN] ESX-MEDIATED TRANSCRIPTION MODULATORS AND RELATED METHODS<br/>[FR] MODULATEURS DE TRANSCRIPTION À MÉDIATION ASSURÉE PAR LE GÈNE ESX ET PROCÉDÉS ASSOCIÉS
  申请人：UNIV MICHGIAN

  公开号：WO2013040436A2

  公开（公告）日：2013-03-21

  The present invention relates to gene regulation. In particular, the present invention provides small compounds capable of modulating ESX-mediated transcription and related methods of therapeutic and research use. In addition, the present invention provides methods for treating conditions associated with aberrant EGFR expression with ESX-mediated transcription modulators (e.g., ESX-mediated transcription inhibitors).