3-(3-dicyclohexylphosphinoylheptanoyl)oxazolidin-2-one | 1128230-26-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-(3-dicyclohexylphosphinoylheptanoyl)oxazolidin-2-one
• 英文别名: 3-(3-Dicyclohexylphosphorylheptanoyl)-1,3-oxazolidin-2-one；3-(3-dicyclohexylphosphorylheptanoyl)-1,3-oxazolidin-2-one
• CAS: 1128230-26-1
• 化学式: C₂₂H₃₈NO₄P
• 分子量: 411.522
• InChiKey: LYKXVZOLBSCNOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (dimethylphenylsilyl)dicyclohexylphosphine 、 (Z)-3-(1-oxo-2-heptenyl)-2-oxazolidinone 在 Pd(2-PyCH=NPh)(OCOC₆F₅)2 、 双氧水 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 18.0h， 以82%的产率得到3-(3-dicyclohexylphosphinoylheptanoyl)oxazolidin-2-one
  参考文献：
  名称：

  Palladium(II)-Catalyzed Conjugate Phosphination of Electron-Deficient Acceptors

  摘要：

  A general protocol for the conjugate transfer of diphenyl-, dicyclohexyl-, and di-tert-butylphosphinyl groups from silylphosphlnes to cyclic and acyclic electron-deficient acceptors employing a bench-stable palladium(II) catalyst Is reported. Several E and Z configured alpha,beta-unsaturated carbonyl and carboxyl acceptors (including imides) as well as nitroalkenes participate in this palladium(II)-catalyzed process in high chemical yields.

  DOI：

  10.1021/ol8028466

文献信息

• Palladium(II)-Catalyzed Conjugate Phosphination of Electron-Deficient Acceptors
  作者：Verena T. Trepohl、Susumu Mori、Kenichiro Itami、Martin Oestreich

  DOI：10.1021/ol8028466

  日期：2009.3.5

  A general protocol for the conjugate transfer of diphenyl-, dicyclohexyl-, and di-tert-butylphosphinyl groups from silylphosphlnes to cyclic and acyclic electron-deficient acceptors employing a bench-stable palladium(II) catalyst Is reported. Several E and Z configured alpha,beta-unsaturated carbonyl and carboxyl acceptors (including imides) as well as nitroalkenes participate in this palladium(II)-catalyzed process in high chemical yields.