2-(N-methyl-ethylamino)-3-chlor-6-amino-5-(N-guanyl-carbamoyl)-pyrazin | 1148-33-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(N-methyl-ethylamino)-3-chlor-6-amino-5-(N-guanyl-carbamoyl)-pyrazin
• 英文别名: 3-amino-6-chloro-5-(ethyl-methyl-amino)-pyrazine-2-carboxylic acid carbamimidoylamide；3-amino-N-carbamimidoyl-6-chloro-5-[ethyl(methyl)amino]pyrazine-2-carboxamide
• CAS: 1148-33-0
• 化学式: C₉H₁₄ClN₇O
• 分子量: 271.709
• InChiKey: RGEKWRRRIQBCSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Method of modulating ion channel functional activity
  申请人：Cox Graeme

  公开号：US20070112013A1

  公开（公告）日：2007-05-17

  The present invention relates generally to a method of retarding, reducing or otherwise inhibiting viral functional activity and, more particularly, to a method of reducing, retarding or otherwise inhibiting viral functional activity by down-regulating Vpu ion channel functional activity. Even more particularly, the present invention provides a method of treating HIV infection or AIDS by inhibiting Vpu ion channel mediated HIV replication.